Invariant Natural Killer T Cells in Immune Regulation of Blood Cancers: Harnessing Their Potential in Immunotherapies.
Invariant Natural Killer T Cells in Immune Regulation of Blood Cancers: Harnessing Their Potential in Immunotherapies.
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DOI：
10.3389/fimmu.2017.01355
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发表时间：
2017
影响因子：
7.3
通讯作者：
Mattarollo SR
中科院分区：
文献类型：
--
作者：
Lam PY;Nissen MD;Mattarollo SR
不变性自然杀伤T细胞（iNKT）是一种独特的先天T淋巴细胞群，具有细胞溶解特性和深刻的免疫调节活性。iNKT细胞在血癌的免疫监测中起着重要作用。它们主要识别CD1d上的糖脂抗原，但它们的激活和细胞溶解活性并不局限于表达CD1d的细胞。iNKT细胞刺激和随后产生的免疫调节细胞因子有助于增强整体抗肿瘤免疫反应。至关重要的是，癌症中iNKT细胞的激活通常先于其他免疫效应细胞（如NK细胞和T细胞）的激活和启动，从而影响抗肿瘤免疫反应的产生和结果。血癌可以通过下调识别受体的表达或主动抑制或转移iNKT细胞的功能来逃避或抑制iNKT细胞的反应。本文将讨论iNKT细胞活性和相关的血癌失调的文献，并重点介绍一些旨在利用和增强iNKT细胞功能对抗血癌的策略。
Invariant natural killer T (iNKT) cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities. iNKT cells play an important role in the immune surveillance of blood cancers. They predominantly recognize glycolipid antigens presented on CD1d, but their activation and cytolytic activities are not confined to CD1d expressing cells. iNKT cell stimulation and subsequent production of immunomodulatory cytokines serve to enhance the overall antitumor immune response. Crucially, the activation of iNKT cells in cancer often precedes the activation and priming of other immune effector cells, such as NK cells and T cells, thereby influencing the generation and outcome of the antitumor immune response. Blood cancers can evade or dampen iNKT cell responses by downregulating expression of recognition receptors or by actively suppressing or diverting iNKT cell functions. This review will discuss literature on iNKT cell activity and associated dysregulation in blood cancers as well as highlight some of the strategies designed to harness and enhance iNKT cell functions against blood cancers.
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影响因子：
7.2
作者：
Bassiri H;Das R;Nichols KE
通讯作者：
Nichols KE
DOI：
10.4049/jimmunol.1401805
发表时间：
2014-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chaudhry MS;Karadimitris A
通讯作者：
Karadimitris A
影响因子：
3.2
作者：
Banchet-Cadeddu, Aline;Henon, Eric;Haudrechy, Arnaud
通讯作者：
Haudrechy, Arnaud
影响因子：
7.3
作者：
Bezu L;Gomes-de-Silva LC;Dewitte H;Breckpot K;Fucikova J;Spisek R;Galluzzi L;Kepp O;Kroemer G
通讯作者：
Kroemer G
DOI：
10.1084/jem.20042592
发表时间：
2005-05-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chang DH;Osman K;Connolly J;Kukreja A;Krasovsky J;Pack M;Hutchinson A;Geller M;Liu N;Annable R;Shay J;Kirchhoff K;Nishi N;Ando Y;Hayashi K;Hassoun H;Steinman RM;Dhodapkar MV
通讯作者：
Dhodapkar MV