Phylogenetic origins and adaptive evolution of avian and mammalian haemoglobin genes
Phylogenetic origins and adaptive evolution of avian and mammalian haemoglobin genes
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鸟类和哺乳动物血红蛋白基因的系统发育起源和适应性进化
作者：
J. Czelusniak;M. Goodman;D. Hewett‐Emmett;M. Weiss;P. Venta;R. Tashian
近年来，珠蛋白的氨基酸序列数据和血红蛋白基因和假基因的核苷酸序列数据迅速增长，这些数据的分支分析1继续揭示珠蛋白进化的新方面。我们目前的研究结果表明：（1）鸟类和哺乳动物胚胎α基因（分别为π和β）具有单系起源，在α和β基因分开的复制后不久，约4亿年前发生了α基因座的复制;（2）在很晚的胚胎发育中，独立的β基因复制产生了鸟类的胚胎ρ基因座和哺乳动物的胚胎β和胎儿γ基因座。这与早期的发现2相似，即肌红蛋白不止一次地从广义球蛋白祖先进化而来。在这里，我们支持这样的珠蛋白的进化是由自然选择作用于重复基因突变的结果。因此，我们的证据与中性论者的观点相矛盾，中性论者认为几乎所有遗传到现存球蛋白的氨基酸取代都逃避了正选择。
Recent years have seen rapid growth in amino acid sequence data on globins and nucleotide sequence data on haemoglobin genes and pseudogenes, and cladistic analysis1 of these data continues to reveal new facets of globin evolution. Our present findings demonstrate: (1) avian and mammalian embryonic α genes (π and ξ, respectively) had a monophyletic origin involving an α locus duplication about 400 Myr ago soon after the duplication which separated α and β genes; (2) much later in phylogeny, independent β-gene duplications produced the embryonic ρ locus of birds and embryonic ɛ and fetal γ loci of mammals. This parallels the earlier finding2 that myoglobins evolved more than once from generalized globin ancestors. Here we support the view2 that such globin evolution resulted from natural selection acting on mutations in duplicated genes. Thus, our evidence contradicts the neutralist view3,4 in which almost all amino acid substitutions in descent to extant globins evaded positive selection.
新鸡胚红珠蛋白的 cDNA 序列。
DOI：
10.1073/pnas.78.8.4782
发表时间：
1981
影响因子：
11.1
作者：
Roninson,IB;Ingram,VM
通讯作者：
Ingram,VM
成年鸡α珠蛋白基因αA和αD：家鸡中不存在贫血性休克α珠蛋白。
DOI：
10.1073/pnas.78.10.5998
发表时间：
1981
影响因子：
11.1
作者：
Dodgson,JB;McCune,KC;Rusling,DJ;Krust,A;Engel,JD
通讯作者：
Engel,JD