Serological analysis of human pandemic influenza (H1N1) in Thailand.
Serological analysis of human pandemic influenza (H1N1) in Thailand.
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DOI：
10.3329/jhpn.v28i6.6601
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Poovorawan Y
中科院分区：
文献类型：
--
作者：
Prachayangprecha S;Makkoch J;Payungporn S;Chieochansin T;Vuthitanachot C;Vuthitanachot V;Theamboonlers A;Poovorawan Y
这项研究的目的是利用实时逆转录聚合酶链式反应确定2009年7月至12月期间呼吸道疾病患者中2009年大流行性流感(H1N1)的流行情况。采用血凝抑制试验检测了2009年12月第二周泰国坤健省255名医务人员、307名普通人群以及2008年从不同年龄段人群中收集的100份储存血清中的大流行性流感抗体效价。结果显示，2009年甲型H1N1流感大流行发生在2009年7月至12月。这次疫情爆发后的HI检测结果显示，从医务人员收集的255份血清中有123份(48%)含有大流行流感抗体，从普通人群获得的307份血清中有109份(36%)，2008年储存的100份血清中只有两份含有针对大流行性流感的抗体(HI效价≥40)。在至少三分之一的人口中发现了2009年甲型H1N1流感大流行抗体。总而言之，研究获得的病毒流行率和血清学数据可以作为7-12月大流行后泰国人口的血清学背景水平。最后，血清学数据可能有助于泰国的暴发预防和控制战略以及2009年H1N1大流行的疫苗接种管理。
The study was aimed at determining the prevalence of pandemic influenza (H1N1) 2009 among patients with respiratory tract diseases during July-December 2009 using real-time reverse transcription polymerase chain reaction. Haemagglutination inhibition (HI) assay was performed to detect antibody titres against pandemic influenza in 255 medical personnel, 307 members of the general population during the second week of December 2009 in Khon Kaen province, Thailand, and in 100 stored sera collected from people of different age-groups during 2008. The results showed that the pandemic (H1N1) 2009 had occurred during July-December 2009. The results of the HI test after the wave of this outbreak showed that 123 (48%) of the 255 sera collected from the medical personnel, 109 (36%) of the 307 sera obtained from the general population, and only two of the 100 stored sera from 2008 contained antibodies (HI titres ≥40) against pandemic influenza. Antibody against the pandemic (H1N1) 2009 was found in at least one-third of the population. In conclusion, the prevalence of virus and serological data obtained from the study can be used as the serological background level of the Thai population after the July-December pandemic. Finally, the serological data might be useful for outbreak-prevention and control strategies and for the management of vaccination for the pandemic (H1N1) 2009 in Thailand.
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