Theta band network supporting human episodic memory is not activated in the seizure onset zone.

Theta band network supporting human episodic memory is not activated in the seizure onset zone.
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支持人类情景记忆的θ波频段网络在癫痫发作起始区未被激活。

DOI:
10.1016/j.neuroimage.2018.08.052
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发表时间:
2018-12
期刊:
影响因子:
5.7
通讯作者:
Baxter MG
Baxter MG
中科院分区:
医学1区
文献类型:
--
作者:
Young JJ;Rudebeck PH;Marcuse LV;Fields MC;Yoo JY;Panov F;Ghatan S;Fazl A;Mandelbaum S;Baxter MG

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情景记忆,即对事件的日常记忆,在癫痫患者中经常受损。我们对接受颅内脑电图(颅内脑电图)监测治疗难治性癫痫的患者进行了测试,这些患者需要情景记忆。我们报道了在需要情景记忆的任务中,以theta-band (4-7 Hz)相干性为特征的解剖扩散网络在目标选择时被激活。当不需要情景记忆时,这种独特的振荡活动网络就不存在了。此外,患者癫痫发作区(SOZ)内的电极中没有θ波段同步网络。我们的数据为支持人类情景记忆的一系列大脑区域提供了新的经验证据,并为癫痫患者观察到的记忆缺陷提供了病理生理机制。
Episodic memory, everyday memory for events, is frequently impaired in patients with epilepsy. We tested patients undergoing intracranial electroencephalography (intracranial EEG) monitoring for the treatment of medically-refractory epilepsy on a well-characterized paradigm that requires episodic memory. We report that an anatomically diffuse network characterized by theta-band (4–7 Hz) coherence is activated at the time of target selection in a task that requires episodic memory. This distinct network of oscillatory activity is absent when episodic memory is not required. Further, the theta band synchronous network was absent in electrodes within the patient’s seizure onset zone (SOZ). Our data provide novel empirical evidence for a set of brain areas that supports episodic memory in humans, and it provides a pathophysiologic mechanism for the memory deficits observed in patients with epilepsy.
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