Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication.

Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication.
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人疱疹病毒6感染引起的细胞周期扰动及其对病毒复制的影响

DOI:
10.1007/s00705-013-1826-0
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发表时间:
2014-03
影响因子:
2.7
通讯作者:
Yao K
Yao K
中科院分区:
医学4区
文献类型:
--
作者:
Li L;Gu B;Zhou F;Chi J;Feng D;Xie F;Wang F;Ma C;Li M;Wang J;Yao K

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在这项研究中,我们证明用人疱疹病毒 6 (HHV-6) 感染 HSB-2 细胞会导致受感染细胞在细胞周期的 G2/M 期积累。对各种细胞周期调节蛋白的分析表明,HHV-6感染的细胞中细胞周期蛋白A2、B1和E1的水平增加,但模拟感染的细胞和HHV-6感染的细胞之间细胞周期蛋白D1的水平没有差异。我们的数据还表明,在 HHV-6 感染的细胞中诱导 G2/M 期停滞为病毒复制提供了有利条件。
In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.
DOI: 10.1074/jbc.m009731200
发表时间: 2001-05-18
期刊: The Journal of biological chemistry
影响因子: --
作者:
Lim KP;Liu DX
通讯作者: Liu DX
DOI: 10.1128/jvi.75.16.7555-7563.2001
发表时间: 2001-08-01
影响因子: 5.4
作者:
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通讯作者: Sugamura, K
DOI: 10.1128/jvi.80.8.4147-4156.2006
发表时间: 2006-04-01
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人类疱疹病毒 6A 感染人类胚胎成纤维细胞并诱导 G2/M 期停滞和细胞死亡
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发表时间: 2012-04-01
影响因子: 12.7
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影响因子: 12.7
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