A T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus.
A T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus.
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DOI：
10.1016/j.clim.2013.12.002
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Tsokos GC
中科院分区：
文献类型：
--
作者：
Grammatikos AP;Kyttaris VC;Kis-Toth K;Fitzgerald LM;Devlin A;Finnell MD;Tsokos GC
系统性红斑狼疮（SLE）仍然是一个具有挑战性的疾病，诊断和遵循，因为没有可靠的生物标志物是已知的日期。我们设计了一个基因表达面板与40个基因已知发挥作用的SLE发病机制。我们发现这些基因在SLE T细胞中的联合表达可以准确地将SLE与健康个体和其他自身免疫性疾病患者区分开来。当仅使用初始基因中的三个（OAS 2、CD70和IL 10）时，测试的准确性进一步增加（83%）。T细胞评分，从这些基因的综合表达水平计算，与各种SLE活动标志物在一个横断面队列和前瞻性随访的少数患者呈正相关。这些数据显示了测量关键分子的mRNA水平在诊断和随访SLE患者中的有用性。
Systemic Lupus Erythematosus (SLE) remains a challenging disease to diagnose and follow, as no reliable biomarkers are known to date. We designed a gene expression panel with 40 genes known to play a role in SLE pathogenesis. We found that the combined expression of these genes in SLE T cells can accurately differentiate SLE from healthy individuals and patients with other autoimmune diseases. The accuracy of the test increased further (83%) when only three out of the initial genes (OAS2, CD70 and IL10) were used. A T cell score, calculated from the combined expression levels of these genes, correlated positively with various SLE activity markers in a cross-sectional cohort and in a few patients that were followed prospectively. These data showcase the usefulness of measuring mRNA levels of key molecules in diagnosing and following patients with SLE.
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影响因子：
2.6
作者：
Juang YT;Peoples C;Kafri R;Kyttaris VC;Sunahori K;Kis-Toth K;Fitzgerald L;Ergin S;Finnell M;Tsokos GC
通讯作者：
Tsokos GC
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
13.6
作者：
Crispín JC;Liossis SN;Kis-Toth K;Lieberman LA;Kyttaris VC;Juang YT;Tsokos GC
通讯作者：
Tsokos GC
影响因子：
4.9
作者：
Moulton VR;Tsokos GC
通讯作者：
Tsokos GC
影响因子：
27.4
作者：
Landolt-Marticorena, C.;Bonventi, G.;Wither, J.
通讯作者：
Wither, J.