The automatic annotation of bacterial genomes.

The automatic annotation of bacterial genomes.
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DOI:
10.1093/bib/bbs007
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发表时间:
2013-01
影响因子:
9.5
通讯作者:
Watson M
Watson M
中科院分区:
生物学2区
文献类型:
--
作者:
Richardson EJ;Watson M

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随着超高通量技术的发展,细菌基因组测序的成本已经大大降低。随着更多的基因组被测序,手动注释这些基因组所花费的时间更少,导致对自动注释管道的依赖增加。然而,自动管道可能会产生不准确的基因组注释,其结果通常需要手动精选。在这里,我们讨论了细菌基因组的自动和手动注释,确定了当前基因组注释过程中引入的常见问题,并提出了潜在的解决方案。
With the development of ultra-high-throughput technologies, the cost of sequencing bacterial genomes has been vastly reduced. As more genomes are sequenced, less time can be spent manually annotating those genomes, resulting in an increased reliance on automatic annotation pipelines. However, automatic pipelines can produce inaccurate genome annotation and their results often require manual curation. Here, we discuss the automatic and manual annotation of bacterial genomes, identify common problems introduced by the current genome annotation process and suggests potential solutions.
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