Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development
Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development
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出生后发育过程中大鼠睾丸中 N-Myc 下游调节基因 2 (NDRG2) 的差异表达
DOI：
10.1007/s00441-009-0814-x
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发表时间：
2009-05
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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作者：
N-Myc下游调控基因2 （NDRG2）在成年动物睾丸中表达，参与细胞分化和发育。然而，关于NDRG2在出生后发育过程中睾丸中的表达模式知之甚少。在这里，我们发现NDRG2在出生后发育的大鼠睾丸间质细胞中一致表达。然而，在幼鼠的精管生精细胞中也检测到它的高频率表达，但在成年大鼠中表达的频率要低得多。此外，在甲氧乙酸诱导的凋亡生殖细胞中发现了高水平的NDRG2表达，特别是在成年大鼠精原上皮周期的X-XIII期。有趣的是，在年轻大鼠和成年大鼠的精小管中自发凋亡的生殖细胞中也观察到高水平的NDRG2表达。因此，在精子发生过程中，生殖细胞中NDRG2的表达似乎发生了改变。这些结果表明，NDRG2调控大鼠睾丸发育和精子发生，并参与生殖细胞的生理性和病理性凋亡。
N-Myc downstream regulated gene 2 (NDRG2) is expressed in the testis of adult animals and is involved in cell differentiation and development. However, little is known about the expression pattern of NDRG2 in the testis during postnatal development. Here, we show that NDRG2 is consistently expressed in Leydig cells in the rat testis during postnatal development. However, its expression has also been detected at a high frequency in spermatogenic cells of the seminiferous tubules in young rats but at a much lower frequency in adult rats. Furthermore, high levels of NDRG2 expression have been found in methoxyacetic-acid-induced apoptotic germ cells, particularly at stages X–XIII of the seminiferous epithelium cycle of adult rats. Interestingly, high levels of NDRG2 expression have also been observed in spontaneously apoptotic germ cells in the seminiferous tubules of young and adult rats. Thus, the expression of NDRG2 in germ cells seems to alter during spermatogenesis. These findings suggest that NDRG2 regulates testicular development and spermatogenesis in rats and is involved in the physiological and pathological apoptosis of germ cells.
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影响因子：
3.6
作者：
Barreiro, ML;Gaytán, F;Tena-Sempere, M
通讯作者：
Tena-Sempere, M
影响因子：
3.6
作者：
Yong Zhao;W. Hou;Hua-ping Zhu;Jie Zhao;Rui‐an Wang;Ruojun Xu;Yuan-qiang Zhang
通讯作者：
Yong Zhao;W. Hou;Hua-ping Zhu;Jie Zhao;Rui‐an Wang;Ruojun Xu;Yuan-qiang Zhang
影响因子：
50.3
作者：
Phillips, HS;Kharbanda, S;Aldape, K
通讯作者：
Aldape, K
DOI：
10.1073/pnas.0709854105
发表时间：
2008-06-17
影响因子：
11.1
作者：
Johnston, Daniel S.;Wright, William W.;Jelinsky, Scott A.
通讯作者：
Jelinsky, Scott A.
影响因子：
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作者：
J. Blanco‐Rodríguez
通讯作者：
J. Blanco‐Rodríguez