Bioaccessibility of polycyclic aromatic hydrocarbons: relevance to toxicity and carcinogenesis.
Bioaccessibility of polycyclic aromatic hydrocarbons: relevance to toxicity and carcinogenesis.
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DOI：
10.1517/17425255.2013.823157
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发表时间：
2013-11
影响因子：
4.3
通讯作者：
Ramesh A
中科院分区：
文献类型：
--
作者：
Harris KL;Banks LD;Mantey JA;Huderson AC;Ramesh A
生物可及性是风险评估领域一个不断发展的研究领域。由于多环芳烃（PAH）是普遍存在的环境污染物，因此它们是确定人类癌症风险的重点毒物。口服摄入的多环芳烃也会引起毒性，甚至影响某些治疗药物的药代动力学行为。为此，生物可及性被用作评估膳食暴露中多环芳烃风险的工具。本综述涵盖了过去五年中使用的一些多环芳烃体外生物可及性模型。本综述还考虑了影响生物可及性的因素，并讨论了使用生物可及性概念来估计摄入多环芳烃污染的土壤和食物的风险的优点和局限性。最后，作者在风险评估的背景下讨论了生物可及性对 PAH 诱导的毒性和癌症的影响。到目前为止，对 PAH 生物可及性的大部分关注都集中在作为优先基质的土壤上。然而，通过饮食摄入的多环芳烃远远超过通过土壤意外摄入的量。因此，生物可及性可以作为评估各种膳食成分受多环芳烃污染的相对风险的工具。虽然生物可及性是评估各种类型污染土壤引起的 PAH 风险的一种有前景的方法，但所提出的模型似乎都无效。来自体外研究的生物可及性值仍需要体内研究的验证。
Bioaccessibility is a growing area of research in the field of risk assessment. As polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, they are the toxicants of focus to establish cancer risks in humans. Orally ingested PAHs also cause toxicity and even affect the pharmacokinetic behavior of some therapeutic agents. Toward this end, bioaccessibility is being used as a tool to assess the risk of PAHs via dietary exposures. This review covers some in vitro bioaccessibility models for PAHs that have been used for the past one-and-a-half decade. This review also considers the factors that influence bioaccessibility and debates the merits and limitations of using a bioaccessibility concept for estimating risk from ingestion of PAH-contaminated soil and food. Finally, the authors discuss the implications of bioaccessibility for PAH-induced toxicity and cancers in the context of risk assessment. So far, much of the focus on PAH bioaccessibility is centered on soil as a preferential matrix. However, ingestion of PAHs through diet far exceeds the amount accidentally ingested through soil. Therefore, bioaccessibility could be exploited as a tool to assess the relative risk of various dietary ingredients tainted with PAHs. While bioaccessibility is a promising approach for assessing PAH risk arising from various types of contaminated soils, none of the models proposed appears to be valid. Bioaccessibility values, derived from in vitro studies, still require validation from in vivo studies.
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影响因子：
2.3
作者：
Gandhi A;Moorthy B;Ghose R
通讯作者：
Ghose R
DOI：
10.1007/s004200100239
发表时间：
2001-08-01
影响因子：
3
作者：
Fiala, Z;Vyskocil, A;Emminger, S
通讯作者：
Emminger, S
影响因子：
4.6
作者：
Gershkovich, P;Hoffman, A
通讯作者：
Hoffman, A
影响因子：
11.4
作者：
Cave, Mark R.;Wragg, Joanna;Daly, Paddy
通讯作者：
Daly, Paddy
影响因子：
4.6
作者：
Gershkovich, Pavel;Hoffman, Amnon
通讯作者：
Hoffman, Amnon