A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.
A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.
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FAM3B 的非分泌形式通过上调 Slug 表达来促进人结肠癌细胞的侵袭和转移。
DOI：
10.1016/j.canlet.2012.09.026
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发表时间：
2013-01-28
期刊：
影响因子：
9.7
通讯作者：
Le Y
中科院分区：
文献类型：
--
作者：
Li Z;Mou H;Wang T;Xue J;Deng B;Qian L;Zhou Y;Gong W;Wang JM;Wu G;Zhou CF;Fang J;Le Y
FAM3B mRNA 预计具有多种剪接形式。其分泌形式PANDER在具有高侵袭性和转移性的胃癌中减少。我们发现其非分泌型FAM3B-258在大多数结肠癌细胞系和结直肠腺癌组织中高表达，但在肝细胞癌、肺癌和胰腺腺癌细胞系中不高表达。 FAM3B-258 的升高与癌细胞分化不良相关。 FAM3B-258在结肠癌细胞中稳定过表达，下调粘附蛋白，上调Slug和Cdc42，促进细胞体外迁移和侵袭以及裸鼠转移。 Slug 介导 FAM3B-258 诱导的粘附分子下调、Cdc42 上调以及结肠癌细胞的侵袭。 FAM3B-258在人结直肠腺癌中的表达与Slug呈正相关。这些结果表明FAM3B-258通过上调Slug来促进结肠癌细胞的侵袭和转移。
FAM3B mRNA has been predicted to have multiple splicing forms. Its secretory form PANDER is decreased in gastric cancers with high invasiveness and metastasis. Here we found that its non-secretory form FAM3B-258 was highly expressed in most colon cancer cell lines and colorectal adenocarcinoma tissues but not hepatocellular carcinoma, lung carcinoma and pancreatic adenocarcinoma cell lines. Elevation of FAM3B-258 was associated with poor cancer cell differentiation. Stable overexpression of FAM3B-258 in colon cancer cells downregulated adhesion proteins, upregulated Slug and Cdc42, promoted cell migration and invasion in vitro and metastasis in nude mice. Slug mediated FAM3B-258-induced downregulation of adhesion molecules, upregulation of Cdc42, and invasion of colon cancer cells. The expression of FAM3B-258 in human colorectal adenocarcinomas was positively correlated with Slug. These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug.
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影响因子：
11.2
作者：
Onder, Tamer T.;Gupta, Piyush B.;Weinberg, Robert A.
通讯作者：
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影响因子：
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DOI：
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期刊：
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影响因子：
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作者：
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作者：
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