Post-translational Modification Control of HBV Biological Processes.
Post-translational Modification Control of HBV Biological Processes.
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HBV 生物过程的翻译后修饰控制
DOI：
10.3389/fmicb.2018.02661
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发表时间：
2018
影响因子：
5.2
通讯作者：
Yang F
中科院分区：
文献类型：
--
作者：
Yang F
B型肝炎病毒感染仍然是一个亟待解决的全球性健康问题。寻找B型肝炎病毒（HBV）感染所致疾病的有效诊断标志物和治疗靶点是抗病毒治疗的新策略。众所周知，不仅病毒蛋白本身，而且来自宿主的关键因子控制与HBV相关的生物学过程，包括复制、转录、包装和分泌。蛋白质翻译后修饰（PTMs），如磷酸化、乙酰化、甲基化和泛素化，已被证明可以控制蛋白质活性、调节蛋白质稳定性、促进蛋白质相互作用和改变蛋白质亚细胞定位，从而调节重要的信号通路和影响细胞过程。本文综述了不同PTMs在调节HBV生命周期重要过程中的功能和作用。PTMs在HBV相关肝病发病机制中的潜在作用也进行了讨论。
Hepatitis B virus infection remains a global healthy issue that needs to be urgently solved. Novel strategies for anti-viral therapy are based on exploring the effective diagnostic markers and therapeutic targets of diseases caused by hepatitis B virus (HBV) infection. It is well-established that not only viral proteins themselves but also key factors from the host control the biological processes associated with HBV, including replication, transcription, packaging, and secretion. Protein post-translational modifications (PTMs), such as phosphorylation, acetylation, methylation, and ubiquitination, have been shown to control protein activity, regulate protein stability, promote protein interactions and alter protein subcellular localization, leading to the modulation of crucial signaling pathways and affected cellular processes. This review focuses on the functions and effects of diverse PTMs in regulating important processes in the HBV life cycle. The potential roles of PTMs in the pathogenesis of HBV-associated liver diseases are also discussed.
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