The impact of childhood parental loss on risk for mood, anxiety and substance use disorders in a population-based sample of male twins.
The impact of childhood parental loss on risk for mood, anxiety and substance use disorders in a population-based sample of male twins.
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DOI：
10.1016/j.psychres.2014.07.053
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发表时间：
2014-12-15
影响因子：
11.3
通讯作者：
Hettema, John M.
中科院分区：
文献类型：
--
作者：
Otowa, Takeshi;York, Timothy P.;Gardner, Charles O.;Kendler, Kenneth S.;Hettema, John M.
以前的研究已经确定了失去父母和以后生活中的精神病理学之间的关系。然而，这种关系取决于损失的类型，涉及的父母和精神病理学的类型。在本研究中，我们研究了来自弗吉尼亚州人口为基础的双胞胎登记处的2605名男性双胞胎的样本中，在儿童时期失去父母（任何损失，死亡和分离）与7种常见精神病和物质使用障碍的终生风险之间的关联。使用结构方程模型（SEM），我们还研究了父母的损失的影响在多大程度上有助于成人精神病理学。父母分离与广泛的成人精神病理学相关，而父母死亡与恐惧症和酒精依赖特别相关。母亲和父亲的分离几乎同样与大多数形式的精神病理学有关。SEM结果表明，父母离异对成人精神病理学的影响约为10%，其中父母离异对抑郁和药物滥用/依赖的影响最大（占总方差的11%）。我们的研究结果表明，早期父母分离有更强和更广泛的影响，对成人精神病理学比父母死亡。
Previous studies have identified the relationship between parental loss and psychopathology later in life. However, this relationship varied depending on the kind of loss, the parent involved, and the type of psychopathology. In the present study, we examined the association between parental loss (any loss, death, and separation) during childhood and lifetime risk for seven common psychiatric and substance use disorders in a sample of 2605 male twins from the Virginia population-based twin registry. Using structural equation modeling (SEM), we also examined the extent to which the influence of parental loss contributes to adult psychopathology. Parental separation was associated with a wide range of adult psychopathology, whereas parental death was specifically associated with phobia and alcohol dependence. Maternal and paternal separation were almost equally associated with most forms of psychopathology. SEM suggested that parental loss accounted for about 10% of the variance of adult psychopathology, of which parental separation had the strongest impacts on risk for depression and drug abuse/dependence (11% of the total variance). Our findings suggest that early parental separation has stronger and wider effects on adult psychopathology than parental death.
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DOI：
10.1176/appi.ajp.2009.08081244
发表时间：
2009-07
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brent D;Melhem N;Donohoe MB;Walker M
通讯作者：
Walker M
影响因子：
5.4
作者：
ISOHANNI, M;OJA, H;KOIRANEN, M
通讯作者：
KOIRANEN, M
影响因子：
5.6
作者：
Clark, Charlotte;Caldwell, Tanya;Stansfeld, Stephen A.
通讯作者：
Stansfeld, Stephen A.
影响因子：
3
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
--
作者：
Hicks, Brian M.;South, Susan C.;DiRago, Ana C.;Iacono, William G.;McGue, Matt
通讯作者：
McGue, Matt