Environmental adversity and increasing genetic risk for externalizing disorders.
Environmental adversity and increasing genetic risk for externalizing disorders.
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DOI：
10.1001/archgenpsychiatry.2008.554
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发表时间：
2009-06
影响因子：
--
通讯作者：
McGue, Matt
中科院分区：
文献类型：
--
作者：
Hicks, Brian M.;South, Susan C.;DiRago, Ana C.;Iacono, William G.;McGue, Matt
关于基因-环境（G-E）相互作用在精神疾病和物质使用障碍发展中的研究正在迅速积累。然而，很少有人试图整合研究结果，并阐明一般机制的G-E的影响出现的精神病理学。确定G-E相互作用的模式外化（EXT;反社会行为和物质使用）障碍和几个环境风险因素之间。我们使用定量遗传模型来研究EXT疾病的遗传和环境风险如何随环境背景而变化。参与者从社区招募，并在大学实验室参加为期一天的评估。样本包括1315名男性和女性双胞胎对参与明尼苏达州双胞胎家庭研究的17岁评估。采用多种测量方法和被调查者构建EXT障碍和6个环境风险因素的复合测量方法，包括学业成绩和参与，反社会和亲社会同伴关系，母子和父子关系问题，以及压力性生活事件。各环境危险因子与EXT之间存在显著的G × E交互作用，环境逆境越大，EXT的遗传风险越大。我们的研究结果表明，在环境逆境的背景下，遗传因素在EXT疾病的病因学中变得更加重要。结果的一致性进一步表明，无论环境风险的具体形式如何，环境影响EXT障碍的一般机制。
Studies of gene-environment (G-E) interplay in the development of psychiatric and substance use disorders are rapidly accumulating. However, few attempts have been made to integrate findings and articulate general mechanisms of G-E influence in the emergence of psychopathology. Identify patterns of G-E interplay between externalizing (EXT; antisocial behavior and substance use) disorders and several environmental risk factors. We used quantitative genetic models to examine how genetic and environmental risk for EXT disorders changes as a function of environmental context. Participants were recruited from the community and took part in a day-long assessment at a university laboratory. The sample consisted of 1315 male and female twin pairs participating in the age 17 assessment of the Minnesota Twin Family Study. Multiple measures and informants were employed to construct a composite of EXT disorders and composite measures of 6 environmental risk factors including academic achievement and engagement, antisocial and prosocial peer affiliation, mother-child and father-child relationship problems, and stressful life events. A significant G × E interaction was detected between each environmental risk factor and EXT such that greater environmental adversity was associated with increased genetic risk in EXT. Our findings demonstrate that in the context of environmental adversity, genetic factors become more important in the etiology of EXT disorders. The consistency of the results further suggests a general mechanism of environmental influence on EXT disorders regardless of the specific form of the environmental risk.
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DOI：
10.1097/00004583-199109000-00009
发表时间：
1991-09-01
影响因子：
13.3
作者：
BARKLEY, RA;ANASTOPOULOS, AD;FLETCHER, KE
通讯作者：
FLETCHER, KE
影响因子：
3
作者：
Iacono, WG;Malone, SM;McGue, M
通讯作者：
McGue, M
影响因子：
3
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
--
作者：
Feinberg, Mark E.;Button, Tanya M. M.;Hetherington, E. Mavis
通讯作者：
Hetherington, E. Mavis
影响因子：
2.6
作者：
Boardman, Jason D.;Saint Onge, Jarron M.;Hewitt, John K.
通讯作者：
Hewitt, John K.