The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche.
The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche.
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DOI：
10.1155/2017/4015039
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发表时间：
2017
影响因子：
4.3
通讯作者：
Figueiredo ML
中科院分区：
文献类型：
--
作者：
Rivera-Cruz CM;Shearer JJ;Figueiredo Neto M;Figueiredo ML
间充质干细胞（MSC）是细胞治疗的一种有前景的工具，特别是其抗肿瘤作用。这种细胞群可以从多种组织来源中分离出来，并且还表现出固有的归巢于炎症区域（例如肿瘤）的能力。进入肿瘤微环境后，间充质干细胞通过多种机制促进或抑制肿瘤进展，主要是通过释放可溶性因子。这些因子可以通过激活或抑制适应性和先天免疫反应来进行免疫调节。间充质干细胞调节免疫反应的机制尚不清楚。正因为如此，肿瘤微环境中的间充质干细胞和免疫细胞之间的关系仍然是一个活跃的研究领域，以帮助解释目前文献中明显矛盾的发现。正在进行的研究旨在增强间充质干细胞在未来治疗应用中的潜力。
Mesenchymal stem cells (MSCs) represent a promising tool for cell therapy, particularly for their antitumor effects. This cell population can be isolated from multiple tissue sources and also display an innate ability to home to areas of inflammation, such as tumors. Upon entry into the tumor microenvironment niche, MSCs promote or inhibit tumor progression by various mechanisms, largely through the release of soluble factors. These factors can be immunomodulatory by activating or inhibiting both the adaptive and innate immune responses. The mechanisms by which MSCs modulate the immune response are not well understood. Because of this, the relationship between MSCs and immune cells within the tumor microenvironment niche continues to be an active area of research in order to help explain the apparent contradictory findings currently available in the literature. The ongoing research aims to enhance the potential of MSCs in future therapeutic applications.
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影响因子：
4.8
作者：
Abomaray, F. M.;Al Jumah, M. A.;Abumaree, M. H.
通讯作者：
Abumaree, M. H.
影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
3.4
作者：
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