Ovarian hormones, aging and stress on hippocampal synaptic plasticity.
Ovarian hormones, aging and stress on hippocampal synaptic plasticity.
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DOI：
10.1016/j.nlm.2010.11.003
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发表时间：
2011-02
影响因子：
2.7
通讯作者：
Foy, Michael R.
中科院分区：
文献类型：
--
作者：
Foy, Michael R.
卵巢类固醇激素雌二醇和孕酮通过与分子和细胞过程相互作用，调节中枢神经系统的各种非生殖功能。越来越多的使用啮齿动物模型进行研究的文献表明，17β-雌二醇是最有效的生物相关雌激素，它可以增强突触传递和从体外海马片记录的长时程增强的幅度。相反，在这个模型系统中，孕酮已经被证明减少突触传递和减少海马区的长时程增强。海马区的长期抑制是突触可塑性的另一种形式，在老年大鼠的脑片中发生得更明显。在海马片组织准备和电生理记录之前，行为应激的成年和老年大鼠的海马片均记录到长时程增强幅度的降低。17β-雌二醇通过增强长期增强和减轻长期抑郁来改变成年和老年大鼠的突触可塑性，无论是否在行为上应激。这篇综述中讨论的研究提供了一种新的方法，用于研究卵巢激素对衰老和压力的保护作用，以及这些激素如何影响与年龄和压力相关的学习和记忆功能障碍。
The ovarian steroid hormones estradiol and progesterone regulate a wide variety of non-reproductive functions in the central nervous system by interacting with molecular and cellular processes. A growing literature from studies using rodent models suggests that 17β-estradiol, the most potent of the biologically relevant estrogens, enhances synaptic transmission and the magnitude of long-term potentiation recorded from in vitro hippocampal slices. In contrast, progesterone has been shown to decrease synaptic transmission and reduce hippocampal long-term potentiation in this model system. Hippocampal long-term depression, another form of synaptic plasticity, occurs more prominently in slices from aged rats. A decrease in long-term potentiation magnitude has been recorded in hippocampal slices from both adult and aged rats behaviorally stressed just prior to hippocampal slice tissue preparation and electrophysiological recording. 17β-estradiol modifies synaptic plasticity in both adult and aged rats, whether behaviorally stressed or not by enhancing long-term potentiation and attenuating long-term depression. The studies discussed in this review provide an understanding of new approaches used to investigate the protective effects of ovarian hormones against aging and stress, and how these hormones impact age and stress-related learning and memory dysfunction.
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DOI：
10.1037/h0077579
发表时间：
1979-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BARNES, CA
通讯作者：
BARNES, CA
DOI：
10.1073/pnas.060034497
发表时间：
2000-03-28
影响因子：
11.1
作者：
Bi, RF;Broutman, G;Baudry, M
通讯作者：
Baudry, M
影响因子：
2
作者：
Foy, Michael R.;Akopian, Garnik;Thompson, Richard F.
通讯作者：
Thompson, Richard F.
影响因子：
120.7
作者：
BARRETTCONNOR, E;KRITZSILVERSTEIN, D
通讯作者：
KRITZSILVERSTEIN, D
影响因子：
3.5
作者：
BARNES, CA;RAO, G;MCNAUGHTON, BL
通讯作者：
MCNAUGHTON, BL