Zn-Mg-WC Nanocomposites for Bioresorbable Cardiovascular Stents: Microstructure, Mechanical Properties, Fatigue, Shelf Life, and Corrosion.
Zn-Mg-WC Nanocomposites for Bioresorbable Cardiovascular Stents: Microstructure, Mechanical Properties, Fatigue, Shelf Life, and Corrosion.
复制标题
DOI：
10.1021/acsbiomaterials.1c01358
复制
发表时间：
2022-01-10
影响因子：
5.8
通讯作者：
Li, Xiaochun
中科院分区：
文献类型：
--
作者：
Guan, Zeyi;Linsley, Chase S.;Pan, Shuaihang;Yao, Gongcheng;Wu, Benjamin M.;Levi, Daniel S.;Li, Xiaochun
锌及锌合金具有良好的生物降解性和生物相容性，在过去的十年中被认为是潜在的生物可吸收支架材料。然而，大多数锌合金缺乏此类应用所需的强度、延展性、抗疲劳性、腐蚀率(CR)和热稳定性的必要组合。本研究将碳化钨(WC)纳米颗粒成功地掺入含0.5wt%镁(Mg)的锌合金中，并对其在BRS应用中的适用性进行了评价。具体地，对所制备的锌-0.5镁-碳化钨纳米复合材料的微观结构、力学性能、体外循环性能和热稳定性进行了评价。锌-0.5镁-碳化钨纳米复合材料具有优异的机械强度[极限拉伸强度(UTS)和250 Mpa]，断裂伸长率(>；30%)，以及适合临床应用的体外CR(~0.02 mm/y)。此外，当最大应力为屈服应力的80%时，锌-0.5镁-碳化钨纳米复合材料经受了1000次拉伸加载(应力比R=0.053)。在90天的热稳定性研究中，它的延展性也得到了保留，这表明它具有极好的保质期。使用这种组合物制造了支架原型，并在台架测试中成功地展开，没有骨折。这些结果表明，Zn-0.5 mg-WC纳米复合材料是一种很有前途的BRS应用材料。体内研究正在进行中，以验证生物相容性、支架功能和降解。
Zinc (Zn) and Zn alloys have been studied as potential materials for bioresorbable stents (BRSs) in the last decade due to their favorable biodegradability and biocompatibility. However, most Zn alloys lack the necessary combination of strength, ductility, fatigue resistance, corrosion rate (CR), and thermal stability needed for such applications. In this study, nanoparticles made of tungsten carbide (WC) were successfully incorporated into Zn alloyed with 0.5 wt % magnesium (Mg) and evaluated for their suitability for BRS applications. Specifically, the resulting Zn–0.5Mg–WC nanocomposite’s microstructure, mechanical properties, in vitro CR, and thermal stability were evaluated. The Zn–0.5Mg–WC nanocomposite had excellent mechanical strength [ultimate tensile strength (UTS) > 250 MPa], elongation to failure (>30%), and a suitable in vitro CR (~0.02 mm/y) for this clinical application. Moreover, the Zn–0.5Mg–WC nanocomposite survived 10 million cycles of tensile loading (stress ratio, R = 0.053) when the maximum stress was 80% of the yield stress. Its ductility was also retained during a 90-day thermal stability study, indicating an excellent shelf life. Stent prototypes were fabricated using this composition and were successfully deployed during bench testing without fracture. These results show that the Zn–0.5Mg–WC nanocomposite is a promising material for BRS applications. In vivo studies are underway to validate both biocompatibility, stent function, and degradation.
登录
查看更多内容
影响因子：
--
作者：
Igbokwe, Ikechukwu Onyebuchi;Igwenagu, Ephraim;Igbokwe, Nanacha Afifi
通讯作者：
Igbokwe, Nanacha Afifi
影响因子：
4.5
作者：
Kuehnel, Dana;Busch, Wibke;Schirmer, Kristin
通讯作者：
Schirmer, Kristin
影响因子：
3
作者：
Guan, Zeyi;Linsley, Chase S.;Li, Xiaochun
通讯作者：
Li, Xiaochun
DOI：
10.1016/j.msec.2020.111172
发表时间：
2020-11-01
影响因子：
7.9
作者：
Chen, Chun;Yue, Rui;Yuan, Guangyin
通讯作者：
Yuan, Guangyin
DOI：
10.1016/j.msea.2019.138529
发表时间：
2020-01-07
影响因子：
6.4
作者：
Ardakani, Morteza S.;Mostaed, Ehsan;Drelich, Jaroslaw W.
通讯作者：
Drelich, Jaroslaw W.