Serum Phosphorus, Serum Bicarbonate, and Renal Function in Relation to Liver CYP1A2 Activity.
Serum Phosphorus, Serum Bicarbonate, and Renal Function in Relation to Liver CYP1A2 Activity.
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DOI：
10.3390/diagnostics13182996
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发表时间：
2023-09-19
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影响因子：
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中科院分区：
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肝脏在正常代谢和酸碱平衡等生理功能中发挥着重要作用；然而，有限的流行病学研究利用非侵入性生物标志物研究了肝脏如何促进酸碱平衡。我们确定了与酸碱平衡和肾功能有关的血清生物标志物与肝脏细胞色素P1A2活性的相关性。我们使用了来自2009-2010年国家健康和营养检查调查(NHANES)的1381名参与者的数据，测量了血清磷、血清碳酸氢盐、咖啡因摄入量、咖啡因代谢物和估计的肾小球滤过率(EGFR)。用尿咖啡因代谢物指数评估肝脏CYP1A2活性，该指数计算为尿咖啡因代谢物之一(即对黄嘌呤和1-甲基尿酸)与咖啡因摄入量的比率。我们基于不同的切入点分析了整个数据集和不同层次的肝脏脂肪变性指数(HSI)之间的相关性。我们发现，在整个数据集中，当比较第四季度和第一季度服用碳酸氢者(对黄嘌呤的β=0.18，p=0.10；1-甲基尿酸的β=0.20，p=0.02)时，血清碳酸氢钠与细胞色素P450酶1A2的活性呈正相关。此外，仅在30≤的HSI和36层中，血清磷与细胞色素P450酶1A2活性呈正相关。最后，在整个数据集和所有具有HSI和42的地层中，较低的EGFR与用对黄嘌呤测量的较低的CYP1A2活性显著相关；当比较EGFR；60和EGFR>；90时，β估计范围从−0.41到−1.38，p值从0.0018到0.004。我们在最高层(HSI≥42)观察到相反的趋势。血清碳酸氢盐、血清磷和表皮生长因子受体的非侵入性测量与细胞色素P1A2活性有动态关联。这些相关性取决于肝脏损伤的程度和用于评估CYP1A2活性的咖啡因代谢物。
The liver plays an important role in normal metabolism and physiological functions such as acid-base balance; however, limited epidemiologic studies have investigated how the liver contributes toward acid-base balance using non-invasive biomarkers. We determined associations between serum biomarkers related to acid-base balance and renal function with liver CYP1A2 activity. We used data from 1381 participants of the 2009–2010 National Health and Nutrition Examination Survey (NHANES) with measurements of serum phosphorus, serum bicarbonate, caffeine intake, caffeine metabolites, and estimated glomerular filtration rate (eGFR). Liver CYP1A2 activity was estimated using urine caffeine metabolite indices, which were calculated as the ratio of one of the urine caffeine metabolites (i.e., paraxanthine and 1-methyluric acid) to caffeine intake. We analyzed associations in the whole data set and in different strata of hepatic steatosis index (HSI) based on different cut-points. We found that serum bicarbonate was positively associated with CYP1A2 activity in the whole data set when comparing persons with bicarbonate at Q4 to Q1 (β = 0.18, p = 0.10 for paraxanthine; β = 0.20, p = 0.02 for 1-methyluric acid). Furthermore, serum phosphorus was positively associated with CYP1A2 activity only in the stratum of 30 ≤ HSI < 36. Lastly, low eGFR was significantly associated with lower CYP1A2 activity measured with paraxanthine in the whole dataset and in all the strata with HSI < 42; when comparing eGFR < 60 to eGFR > 90, β estimates ranged from −0.41 to −1.38, p-values ranged from 0.0018 to 0.004. We observed an opposite trend in the highest stratum (HSI ≥ 42). Non-invasive measurements of serum bicarbonate, serum phosphorus, and eGFR have dynamic associations with CYP1A2 activity. These associations depend on the extent of liver damage and the caffeine metabolite used to assess CYP1A2 activity.
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DOI：
10.3390/ijerph18052225
发表时间：
2021-02-24
影响因子：
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作者：
Garduno A;Wu T
通讯作者：
Wu T
影响因子：
9.8
作者：
COHEN, RD
通讯作者：
COHEN, RD
影响因子：
4
作者：
Adeva-Andany MM;Pérez-Felpete N;Fernández-Fernández C;Donapetry-García C;Pazos-García C
通讯作者：
Pazos-García C
影响因子：
4.5
作者：
Lee, Jeong-Hoon;Kim, Donghee;Lee, Hyo-Suk
通讯作者：
Lee, Hyo-Suk
影响因子：
6.1
作者：
Hakkola J;Hukkanen J;Turpeinen M;Pelkonen O
通讯作者：
Pelkonen O