Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation
Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation
复制标题
碳离子照射下氧化钆纳米晶对NSCLC细胞的放射增敏作用
DOI：
10.1186/s11671-019-3152-2
复制
发表时间：
2019-10
影响因子：
--
通讯作者：
Qiang Li
中科院分区：
文献类型：
--
作者：
Feifei Li;Zihou Li;Xiaodong Jin;Yan Liu;Ping Li;Zheyu Shen;Aiguo Wu;Xiaogang Zheng;Weiqiang Chen;Qiang Li
摘要钆基纳米材料不仅可以作为造影剂，而且在肿瘤的放射治疗中具有增敏作用。在放射治疗中，碳离子照射被认为是具有独特物理和生物学优势的上级方法之一。然而，只有少数金属纳米颗粒被用于改善碳离子辐照。在这项研究中，氧化钆纳米晶体（GONs）的合成使用多元醇的方法来破译的放射增敏机制在非小细胞肺癌（NSCLC）细胞株照射碳离子。在10%的生存水平的敏化剂增强比与Gd在NSCLC细胞中的浓度相关。GONs可引起细胞内羟自由基产生量的增加，并呈浓度依赖性，细胞内活性氧产生量明显增加，导致DNA损伤和细胞周期阻滞。在碳离子照射下，GONs也能显著诱导细胞凋亡和细胞抑制性自噬。GON有望成为非小细胞肺癌碳离子放疗的有效治疗诊断材料。
AbstractGadolinium-based nanomaterials can not only serve as contrast agents but also contribute to sensitization in the radiotherapy of cancers. Among radiotherapies, carbon ion irradiation is considered one of the superior approaches with unique physical and biological advantages. However, only a few metallic nanoparticles have been used to improve carbon ion irradiation. In this study, gadolinium oxide nanocrystals (GONs) were synthesized using a polyol method to decipher the radiosensitizing mechanisms in non-small cell lung cancer (NSCLC) cell lines irradiated by carbon ions. The sensitizer enhancement ratio at the 10% survival level was correlated with the concentration of Gd in NSCLC cells. GONs elicited an increase in hydroxyl radical production in a concentration-dependent manner, and the yield of reactive oxygen species increased obviously in irradiated cells, which led to DNA damage and cell cycle arrest. Apoptosis and cytostatic autophagy were also significantly induced by GONs under carbon ion irradiation. The GONs may serve as an effective theranostic material in carbon ion radiotherapy for NSCLC.Graphical Abstract
登录
查看更多内容
影响因子：
4.6
作者：
Amornwichet N;Oike T;Shibata A;Nirodi CS;Ogiwara H;Makino H;Kimura Y;Hirota Y;Isono M;Yoshida Y;Ohno T;Kohno T;Nakano T
通讯作者：
Nakano T
辐射增强效应对暴露于低和高 LET 辐射的金纳米颗粒浓度的依赖性
DOI：
10.1016/j.ejmp.2015.01.006
发表时间：
2015-05-01
影响因子：
3.4
作者：
Liu, Yan;Liu, Xi;Li, Qiang
通讯作者：
Li, Qiang
影响因子：
8
作者：
Li, Feifei;Li, Zihou;Li, Qiang
通讯作者：
Li, Qiang
影响因子：
10.2
作者：
Lopes VR;Loitto V;Audinot JN;Bayat N;Gutleb AC;Cristobal S
通讯作者：
Cristobal S
DOI：
10.1016/j.nano.2017.07.015
发表时间：
2017-11
期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
--
作者：
A. Wozny;M. Aloy;Gersende Alphonse;N. Magné;M. Janier;O. Tillement;F. Lux;M. Beuve;C. Rodriguez-Lafras
通讯作者：
A. Wozny;M. Aloy;Gersende Alphonse;N. Magné;M. Janier;O. Tillement;F. Lux;M. Beuve;C. Rodriguez-Lafras