Early-Life Enteric Pathogen Exposure, Socioeconomic Status, and School-Age Cognitive Outcomes.
Early-Life Enteric Pathogen Exposure, Socioeconomic Status, and School-Age Cognitive Outcomes.
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DOI：
10.4269/ajtmh.22-0584
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发表时间：
2023-08-02
期刊：
影响因子：
--
通讯作者：
Guerrant RL
中科院分区：
文献类型：
--
作者：
Scharf RJ;McQuade ETR;Svensen E;Huggins A;Maphula A;Bayo E;Blacy L;Pamplona E de Souza P;Costa H;Houpt ER;Bessong PO;Mduma E;Lima AAM;Guerrant RL
在资源匮乏的环境中，早年经历肠道感染和腹泻病是很常见的，据推测会影响儿童的发育。然而，由于缺乏长期研究，肠道感染与学龄期认知结果的长期关联难以估计。本研究的目的是在巴西、坦桑尼亚和南非的低资源环境中，研究从出生到6 - 8岁的一组儿童中，生命最初2年的肠道病原体暴露与学龄期认知技能之间的关系。该研究包括来自病因学，风险因素和肠道感染与营养不良的相互作用以及儿童健康后果研究的三个研究中心的参与者，他们在出生后立即入组，并随访肠道感染，肠道疾病和认知发育，直到2岁。当孩子们到了学龄期，进一步收集了推理技能和语义/音素流畅性的数据。我们使用线性回归和调整混杂变量，估计了0 - 2年特定肠道病原体和病原学特异性腹泻负担与6 - 8年认知测试评分之间的相关性。在这项研究中，在生命的前2年携带更多肠道病原体的儿童表现出学龄期认知能力的整体下降，特别是携带原虫的儿童，尽管这在该样本中没有统计学意义。社会经济因素，如母亲的教育和收入与学龄认知能力更密切相关。早期生活肠道病原体可能对学龄期认知结果有一个小的，持久的影响，尽管其他社会经济因素可能贡献更大。
Early-life experiences of enteric infections and diarrheal illness are common in low-resource settings and are hypothesized to affect child development. However, longer-term associations of enteric infections with school-age cognitive outcomes are difficult to estimate due to lack of long-term studies. The objective of this study was to examine the relationship between enteropathogen exposure in the first 2 years of life with school-age cognitive skills in a cohort of children followed from birth until 6 to 8 years in low-resource settings in Brazil, Tanzania, and South Africa. The study included participants from three sites from the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health Study who were enrolled just after birth and followed for enteric infections, diarrheal illness, and cognitive development until 2 years of age. When the children were school-age, further data were collected on reasoning skills and semantic/phonemic fluency. We estimated associations between the burden of specific enteric pathogens and etiology-specific diarrhea from 0 to 2 years with cognitive test scores at 6 to 8 years using linear regression and adjusting for confounding variables. In this study, children who carried more enteric pathogens in the first 2 years of life showed overall decreases in school-age cognitive abilities, particularly children who carried protozoa, although this was not statistically significant in this sample. Socioeconomic factors such as maternal education and income were more closely associated with school-age cognitive abilities. Early-life enteric pathogens may have a small, lasting influence on school-age cognitive outcomes, although other socioeconomic factors likely contribute more significantly.
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影响因子：
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作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
3.3
作者：
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