Pre-eclampsia in pregnancy and subsequent risk for breast cancer.
Pre-eclampsia in pregnancy and subsequent risk for breast cancer.
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妊娠前的子痫前期以及随后患乳腺癌的风险。
DOI：
10.1038/sj.bjc.6600581
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发表时间：
2002-10-21
影响因子：
8.8
通讯作者：
Skjærven, R
中科院分区：
文献类型：
--
作者：
Vatten, LJ;Romundstad, PR;Trichopoulos, D;Skjærven, R
怀孕期间患有先兆子痫或高血压的女性在以后的生活中患乳腺癌的风险可能会降低。证据基于病例对照研究，在这里我们报告了一项队列研究的结果，该研究探讨了第一次怀孕时诊断出的先兆子痫和妊娠期高血压与随后患乳腺癌的风险之间的联系。我们综合了挪威医学出生登记处和癌症登记处的信息，这两个登记处都是全国性的。从 1967 年建立出生登记到 1998 年，记录了 694 657 名妇女的第一胎，并根据第一次怀孕时是否诊断出先兆子痫和/或高血压进行分类。与挪威癌症登记处的联系确定了 5474 例在首次分娩后诊断出的新乳腺癌病例。与其他经产女性相比，在对达到的年龄、诊断日历周期、首次生育年龄和产次进行调整后，在第一次怀孕时诊断出先兆子痫和/或高血压的女性患乳腺癌的风险降低了 19%（95% 置信区间，9% 至 29%）。对于足月分娩和早产、不同后代出生体重范围以及绝经前和绝经后妇女，这一结果相似。这些结果表明，先兆子痫和妊娠高血压的病理生理学在乳腺癌病因学中起着重要作用。更好地了解潜在过程可以深入了解乳腺癌的发病机制。英国癌症杂志 (2002) 87, 971–973。 doi:10.1038/sj.bjc.6600581 www.bjcancer.com © 2002 英国癌症研究中心
Women who experience pre-eclampsia or hypertension during pregnancy may have a reduced risk for breast cancer later in life. The evidence is based on case–control studies, and here we report the results of a cohort study exploring the link between pre-eclampsia and gestational hypertension diagnosed in the first pregnancy and subsequent risk for breast cancer. We combined information from the Medical Birth Registry and the Cancer Registry in Norway, which are both nation-wide. Between 1967, when the birth registry was established, and 1998, 694 657 women were recorded with a first birth, and classified according to whether pre-eclampsia and/or hypertension was diagnosed in the first pregnancy. Linkage to the Norwegian Cancer Registry identified 5474 new cases of breast cancer diagnosed subsequently to their first delivery. Compared to other parous women, women with pre-eclampsia and/or hypertension diagnosed in their first pregnancy had 19% lower risk (95% confidence interval, 9 to 29%) for breast cancer, after adjustment for attained age, calendar period of diagnosis, age at first birth, and parity. This result was similar for term and preterm deliveries, across the range of offspring birth weight, and for pre- and postmenopausal women. These results suggest that the pathophysiology surrounding pre-eclampsia and gestational hypertension plays an important role in breast cancer etiology. A better understanding of the underlying processes could provide an insight into the pathogenesis of breast cancer. British Journal of Cancer (2002) 87, 971–973. doi:10.1038/sj.bjc.6600581 www.bjcancer.com © 2002 Cancer Research UK
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影响因子：
10.3
作者：
THOMPSON, WD;JACOBSON, HI;JANERICH, DT
通讯作者：
JANERICH, DT
DOI：
10.1093/jnci/93.15.1133
发表时间：
2001-08-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Cohn, BA;Cirillo, PM;Siiteri, PK
通讯作者：
Siiteri, PK
影响因子：
5.4
作者：
Innes, KE;Byers, TE
通讯作者：
Byers, TE
DOI：
10.1016/s0002-9378(96)70056-x
发表时间：
1996-11-01
影响因子：
9.8
作者：
Ness, RB;Roberts, JM
通讯作者：
Roberts, JM
影响因子：
5.5
作者：
KELSEY, JL
通讯作者：
KELSEY, JL