Endocrine disruptors in female reproductive tract development and carcinogenesis.
Endocrine disruptors in female reproductive tract development and carcinogenesis.
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女性生殖道发育和癌变中的内分泌干扰物。
DOI：
10.1016/j.tem.2009.03.009
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发表时间：
2009-09
影响因子：
10.9
通讯作者：
Ma, Liang
中科院分区：
文献类型：
--
作者：
Ma, Liang
对内分泌干扰物(EDCs)及其对胎儿发育和成人健康影响的日益关注，推动了对内分泌干扰物潜在分子机制的研究。基因打靶技术使人们能够洞察控制生殖道发育的遗传途径，以及在关键的发育窗口期间暴露于EDCs如何改变生殖道发育，从而有可能形成成人疾病的基础。本文主要以己烯雌酚(DES)为模型药物，从分子水平阐明己烯雌酚等EDCs对小鼠生殖道发育和肿瘤的影响。
Growing concerns over endocrine disrupting chemicals (EDCs) and their effects on human fetal development and adult health have promoted research into the underlying molecular mechanisms of endocrine disruption. Gene targeting technology has allowed insight into the genetic pathways governing reproductive tract development and how exposure to EDCs during a critical developmental window can alter reproductive tract development, potentially forming the basis for adult diseases. This review primarily uses diethylstilbestrol (DES) as a model agent for EDCs and discusses the recent progress elucidating how DES and other EDCs affect murine female reproductive tract development and cancer at the molecular level.
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影响因子：
11.8
作者：
Carroll, TJ;Park, JS;McMahon, AP
通讯作者：
McMahon, AP
影响因子：
2.7
作者：
Guioli, Silvana;Sekido, Ryohei;Lovell-Badge, Robin
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Korach, KS
影响因子：
2.7
作者：
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通讯作者：
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