Molecular Crosstalk Between MYC and HIF in Cancer.
Molecular Crosstalk Between MYC and HIF in Cancer.
复制标题
DOI：
10.3389/fcell.2020.590576
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Dai MS
中科院分区：
文献类型：
--
作者：
Li Y;Sun XX;Qian DZ;Dai MS
转录因子c-MYC（以下简称MYC）是基因表达的全局调节因子。它在不同来源的人类癌症中过表达或失调，并在癌症的发展中起关键作用。低氧诱导因子（HIF）是细胞适应低细胞氧水平的中心调节因子，在许多人类癌症中也经常过表达和激活。HIF介导多种基因对缺氧的初级转录反应。早期的研究主要集中在低氧条件下，当MYC在生理水平表达时，HIF抑制MYC，以帮助细胞在低氧条件下存活。新出现的证据表明，MYC和HIF也合作促进癌细胞的生长和进展。本文就MYC和HIF之间复杂的分子相互作用的研究进展作一综述。
The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is overexpressed or deregulated in human cancers of diverse origins and plays a key role in the development of cancers. Hypoxia-inducible factors (HIFs), a central regulator for cells to adapt to low cellular oxygen levels, is also often overexpressed and activated in many human cancers. HIF mediates the primary transcriptional response of a wide range of genes in response to hypoxia. Earlier studies focused on the inhibition of MYC by HIF during hypoxia, when MYC is expressed at physiological level, to help cells survive under low oxygen conditions. Emerging evidence suggests that MYC and HIF also cooperate to promote cancer cell growth and progression. This review will summarize the current understanding of the complex molecular interplay between MYC and HIF.
登录
查看更多内容
DOI：
10.1038/s41580-020-0215-2
发表时间：
2020-05
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Baluapuri A;Wolf E;Eilers M
通讯作者：
Eilers M
影响因子：
16.6
作者：
Bailey ST;Smith AM;Kardos J;Wobker SE;Wilson HL;Krishnan B;Saito R;Lee HJ;Zhang J;Eaton SC;Williams LA;Manocha U;Peters DJ;Pan X;Carroll TJ;Felsher DW;Walter V;Zhang Q;Parker JS;Yeh JJ;Moffitt RA;Leung JY;Kim WY
通讯作者：
Kim WY
影响因子：
5.3
作者：
Cowling, Victoria H.;Chandriani, Sanjay;Cole, Michael D.
通讯作者：
Cole, Michael D.
影响因子：
28.2
作者：
Cantor JR;Sabatini DM
通讯作者：
Sabatini DM
DOI：
10.1073/pnas.93.23.12969
发表时间：
1996-11-12
影响因子：
11.1
作者：
Arany, Z;Huang, LE;Livingston, DM
通讯作者：
Livingston, DM