MDMA effects consistent across laboratories.
MDMA effects consistent across laboratories.
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DOI：
10.1007/s00213-014-3528-z
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发表时间：
2014-10
影响因子：
3.4
通讯作者：
de Wit, Harriet
中科院分区：
文献类型：
--
作者：
Kirkpatrick, Matthew G.;Baggott, Matthew J.;Mendelson, John E.;Galloway, Gantt P.;Liechti, Matthias E.;Hysek, Cedric M.;de Wit, Harriet
几个实验室已经用MDMA进行了安慰剂对照药物挑战研究，提供了独特的数据来源，以检查药物在受试者样本和环境中急性效应的可靠性。我们在三个不同的实验室检查了对药物的主观和生理反应，并调查了先前使用MDMA的影响。总体而言，220名既往有不同程度MDMA经验的健康志愿者参加了基于实验室的研究，在这些研究中，他们在双盲条件下接受安慰剂或口服MDMA（1.5 mg/kg或125 mg固定剂量）。在给药前和给药后反复评估心血管和主观效应。这些研究由巴塞尔、弗朗西斯科和芝加哥的研究人员独立进行。尽管研究方法存在差异，受试者的药物使用史也存在差异，但MDMA在各研究中心产生的心血管和主观效应非常相似。参与者先前使用MDMA与感觉“任何药物作用”呈负相关，仅在测试更有经验的用户的网站。这些数据表明，MDMA的药理学作用是稳健的，并且在不同环境下具有高度重现性。也有少量证据表明，经常使用者对摇头丸的影响具有耐受性。
Several laboratories have conducted placebo-controlled drug challenge studies with MDMA, providing a unique source of data to examine the reliability of the acute effects of the drug across subject samples and settings. We examined the subjective and physiological responses to the drug across three different laboratories, and investigated the influence of prior MDMA use. Overall, 220 healthy volunteers with varying levels of previous MDMA experience participated in laboratory-based studies in which they received placebo or oral MDMA (1.5 mg/kg or 125 mg fixed dose) under double blind conditions. Cardiovascular and subjective effects were assessed before and repeatedly after drug administration. The studies were conducted independently by investigators in Basel, San Francisco and Chicago. Despite methodological differences between the studies and differences in the subjects' drug use histories, MDMA produced very similar cardiovascular and subjective effects across the sites. The participants' prior use of MDMA was inversely related to feeling `Any Drug Effect' only at sites testing more experienced users. These data indicate that the pharmacological effects of MDMA are robust and highly reproducible across settings. There was also modest evidence for tolerance to the effects of MDMA in regular users.
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DOI：
10.1111/j.1749-6632.1998.tb08233.x
发表时间：
1998-01-01
期刊：
NEUROCHEMISTRY OF DRUGS OF ABUSE
影响因子：
--
作者：
Frederick, DL;Ali, SF;Paule, MG
通讯作者：
Paule, MG
影响因子：
3.7
作者：
Studerus E;Gamma A;Kometer M;Vollenweider FX
通讯作者：
Vollenweider FX
影响因子：
6
作者：
Degenhardt, L;Barker, B;Topp, L
通讯作者：
Topp, L
影响因子：
4.6
作者：
CARLIN, AS;BAKKER, CB;POST, RD
通讯作者：
POST, RD
影响因子：
1.7
作者：
Verheyden, SL;Henry, JA;Curran, HV
通讯作者：
Curran, HV