Prediction of psilocybin response in healthy volunteers.
Prediction of psilocybin response in healthy volunteers.
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DOI：
10.1371/journal.pone.0030800
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Vollenweider FX
中科院分区：
文献类型：
--
作者：
Studerus E;Gamma A;Kometer M;Vollenweider FX
对致幻剂（如裸盖菇素）的反应被认为是严重依赖于用户的个性，当前的情绪状态，药物前的经验，预期，以及社会和环境变量。然而，鲜为人知的是，这些变量的重要性和它们的影响大小相比，药物剂量的顺序。因此，本研究探讨了24个预测变量，包括年龄，性别，教育，人格特质，药物前的经验，服药前的精神状态，实验设置和药物剂量对裸盖菇素的急性反应的影响。该分析基于23项对照实验研究的汇总数据，涉及261名健康志愿者的409次裸盖菇素给药。对15个响应变量中的每一个拟合多线性混合效应模型。虽然药物剂量显然是所有测量的反应变量的最重要的预测因子，几个非药理学变量显着贡献裸盖菇素的影响。具体来说，在吸收人格特质中得分高，在服用药物前处于情绪兴奋和活跃状态，以及在过去几周内经历了很少的心理问题，与愉快和神秘类型的经历密切相关，而高情绪兴奋性，低年龄，以及涉及正电子发射断层扫描的实验设置最强烈地预测了对裸盖菇素的不愉快和/或焦虑反应。结果证实，非药理学变量在裸盖菇素的作用中起重要作用。
Responses to hallucinogenic drugs, such as psilocybin, are believed to be critically dependent on the user's personality, current mood state, drug pre-experiences, expectancies, and social and environmental variables. However, little is known about the order of importance of these variables and their effect sizes in comparison to drug dose. Hence, this study investigated the effects of 24 predictor variables, including age, sex, education, personality traits, drug pre-experience, mental state before drug intake, experimental setting, and drug dose on the acute response to psilocybin. The analysis was based on the pooled data of 23 controlled experimental studies involving 409 psilocybin administrations to 261 healthy volunteers. Multiple linear mixed effects models were fitted for each of 15 response variables. Although drug dose was clearly the most important predictor for all measured response variables, several non-pharmacological variables significantly contributed to the effects of psilocybin. Specifically, having a high score in the personality trait of Absorption, being in an emotionally excitable and active state immediately before drug intake, and having experienced few psychological problems in past weeks were most strongly associated with pleasant and mystical-type experiences, whereas high Emotional Excitability, low age, and an experimental setting involving positron emission tomography most strongly predicted unpleasant and/or anxious reactions to psilocybin. The results confirm that non-pharmacological variables play an important role in the effects of psilocybin.
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影响因子：
10.6
作者：
Frokjaer, Vibe G.;Mortensen, Erik L.;Knudsen, Gitte M.
通讯作者：
Knudsen, Gitte M.
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2009-08-01
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