Lens thickness with age and accommodation by optical coherence tomography.
Lens thickness with age and accommodation by optical coherence tomography.
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DOI：
10.1111/j.1475-1313.2008.00594.x
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Zadnik K
中科院分区：
文献类型：
--
作者：
Richdale K;Bullimore MA;Zadnik K
利用时域光学相干断层扫描（OCT）测量晶状体透镜随年龄和调节的变化。进行了一项老视前和老视受试者的横断面研究。用上推试验测量调节幅度。用Grand Seiko自动验光仪和Badal透镜系统测量客观调节。使用Zeiss Visante OCT和内部视力计测量透镜厚度。使用相关系数、线性回归和通过计算客观调节中每屈光度变化的透镜厚度的平均变化来分析数据。年龄在36岁至50岁之间的22名受试者完成了研究。主观调节幅度为2.17 ~ 6.38D。客观调节范围为0.22 ~ 4.56D。平均透镜厚度为4.05 ± 0.20 mm。透镜厚度的平均变化范围为0.01至0.26 mm。相关系数为：年龄与主观调节，r =-0.74;年龄与客观调节，r =-0.84;透镜厚度变化与年龄，r =-0.65;透镜厚度变化与主观调节，r = 0.74;透镜厚度变化与客观调节，r = 0.64;客观调节与主观调节，r = 0.82;（均P < 0.01）。通过线性回归确定透镜厚度每岁增加21 μm。对于在Grand Seiko自动验光仪上显示出至少1 D屈光度反应的受试者，每屈光度调节增加51 ± 19 μm。OCT是一种非侵入性技术，可用于量化晶体透镜厚度的变化。主观和客观测量的调节，以及年龄，与透镜厚度的测量变化强相关。使用Visante OCT测量的透镜厚度随年龄和调节的变化与使用Scheimpflug摄影和超声的先前结果比较良好。
To utilize time-domain optical coherence tomography (OCT) to measure changes in the crystalline lens with age and accommodation. A cross-sectional study of pre-presbyopic and presbyopic subjects was conducted. Amplitude of accommodation was measured with the push-up test. Objective accommodation was measured with the Grand Seiko auto-refractor and a Badal lens system. Lens thickness was measured with the Zeiss Visante OCT and an internal optometer. The data were analyzed using correlation coefficients, linear regression, and by calculating the average change in lens thickness per diopter change in objective accommodation. Twenty-two subjects between the ages of 36 and 50 years completed the study. Subjective amplitude of accommodation ranged from 2.17 to 6.38 D. Objective accommodation ranged from 0.22 to 4.56 D. The mean lens thickness was 4.05 ± 0.20 mm. The mean change in lens thickness for up to a 5-D accommodative stimulus ranged from 0.01 to 0.26 mm. The correlation coefficients were: age and subjective accommodation, r = −0.74; age and objective accommodation, r = −0.84; change in lens thickness and age, r = −0.65; change in lens thickness and subjective accommodation, r = 0.74; change in lens thickness and objective accommodation, r = 0.64; objective and subjective accommodation, r = 0.82; (all p < 0.01). An increase in lens thickness of 21 μm per year of age was determined by linear regression. For the subjects who showed at least 1 D of accommodative response on the Grand Seiko auto-refractor, there was an increase of 51 ± 19 μm per diopter of accommodation. OCT is a non-invasive technique that can be used to quantify changes in the thickness of the crystalline lens. Subjective and objective measurements of accommodation, as well as age, were robustly correlated with the measured changes in lens thickness. Lens thickness changes with age and accommodation as measured with the Visante OCT compare well with previous findings using Scheimpflug photography and ultrasound.
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