Metabolic syndrome components and colorectal adenoma in the CLUE II cohort.
Metabolic syndrome components and colorectal adenoma in the CLUE II cohort.
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DOI：
10.1007/s10552-009-9428-6
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发表时间：
2010-01
影响因子：
2.3
通讯作者：
Platz, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Tsilidis, Konstantinos K.;Brancati, Frederick L.;Pollak, Michael N.;Rifai, Nader;Clipp, Sandra L.;Hoffman-Bolton, Judith;Helzlsouer, Kathy J.;Platz, Elizabeth A.
在一些研究中，代谢综合征组分与结直肠癌相关;然而，结直肠腺瘤的证据有限。因此，我们在一项巢式病例对照研究中评估了代谢综合征标志物与结直肠腺瘤发展之间的关系。在马里兰州华盛顿县的CLUE II队列研究中，在1989年至2000年的基线期间，确定了结直肠腺瘤病例（n= 132）和乙状结肠镜检查或结肠镜检查阴性的对照组（n=260）。在基线血液标本中测量C肽、胰岛素样生长因子结合蛋白-1、糖化血红蛋白、总胆固醇、高密度脂蛋白胆固醇和甘油三酯的浓度。使用基线身高和体重计算体重指数。基线时自我报告使用药物治疗糖尿病。在基线时测量血压。后者标志物的分布临界点用于定义基线时存在的代谢综合征组分（高胰岛素血症、高血糖症、肥胖、血脂异常和高血压）。代谢综合征标志物与腺瘤之间没有统计学显著相关性，但与糖尿病药物使用之间存在强正相关性（OR，8.00; 95%CI，1.70 - 37.67），尽管基于小数量。我们的研究结果不支持代谢综合征的成分影响结直肠腺瘤的风险，除了可能是严重的糖尿病药物治疗。
Metabolic syndrome components have been associated with colorectal cancer in several studies; however, the evidence for colorectal adenomas is limited. Thus, we evaluated the association between markers of the metabolic syndrome with colorectal adenoma development in a nested case-control study. Colorectal adenoma cases (n= 132) and matched controls who had had a negative sigmoidoscopy or a colonoscopy (n=260) were identified between baseline in 1989 and 2000 among participants in the CLUE II cohort of Washington County, Maryland. Concentrations of C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, total cholesterol, high density lipoprotein-cholesterol, and triglycerides were measured in baseline blood specimens. Body mass index was calculated using baseline height and weight. Use of medications to treat diabetes mellitus was self-reported at baseline. Blood pressure was measured at baseline. Distributional cutpoints of the latter markers were used to define the metabolic syndrome components (hyperinsulinemia, hyperglycemia, obesity, dyslipidemia, and hypertension) present at baseline. No statistically significant associations with adenomas were observed for the markers of the metabolic syndrome, with the exception of a strong positive association for use of diabetes medications (OR, 8.00; 95% CI, 1.70 – 37.67), albeit based on small numbers. Our findings do not support that components of the metabolic syndrome influence risk of colorectal adenomas, except possibly for severe diabetes mellitus warranting medical treatment.
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影响因子：
6.4
作者：
Jenab, Mazda;Riboli, Elio;Kaaks, Rudolf
通讯作者：
Kaaks, Rudolf
影响因子：
5
作者：
Bowers, Katherine;Albanes, Demetrius;Stolzenberg-Solomon, Rachael
通讯作者：
Stolzenberg-Solomon, Rachael
影响因子：
8.8
作者：
Järvinen, R;Knekt, P;Heliövaara, M
通讯作者：
Heliövaara, M
DOI：
10.1089/154099903321576574
发表时间：
2003-03-01
期刊：
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
影响因子：
--
作者：
Giovannucci, E
通讯作者：
Giovannucci, E
影响因子：
1.9
作者：
Gaard, M;Tretli, S;Urdal, P
通讯作者：
Urdal, P