Innovation in academic chemical screening: filling the gaps in chemical biology.
Innovation in academic chemical screening: filling the gaps in chemical biology.
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DOI：
10.1016/j.cbpa.2013.04.018
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发表时间：
2013-06
影响因子：
7.8
通讯作者：
Inglese, James
中科院分区：
文献类型：
--
作者：
Hasson, Samuel A.;Inglese, James
世界各地的学术筛选中心一直在努力发现可以调节生物系统的小分子。为了扩大功能基因组和化学筛选计划的覆盖面，大学、研究机构和政府已经效仿工业同行采用高通量范例。随着学术筛选工作在范围和复杂性上稳步增长，关于技术和生物学结合的可能性的想法也在稳步增长。这篇综述介绍了最近的概念和技术创新，这些创新一直在推动学术筛选进入其独特的利基市场。特别是，高含量和全生物体的筛选正在改变学者寻找新的生物活性化合物的方式。重要的是，我们认识到成功开发化学探针的例子，这些例子突显了不断变化的技术格局。
Academic screening centers across the world have endeavored to discover small molecules that can modulate biological systems. To increase the reach of functional-genomic and chemical screening programs, universities, research institutes, and governments have followed their industrial counterparts in adopting high-throughput paradigms. As academic screening efforts have steadily grown in scope and complexity, so have the ideas of what is possible with the union of technology and biology. This review addresses the recent conceptual and technological innovation that has been propelling academic screening into its own unique niche. In particular, high-content and whole-organism screening is changing how academics search for novel bioactive compounds. Importantly, we recognize examples of successful chemical probe development that have punctuated the changing technology landscape.
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影响因子：
3.8
作者：
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通讯作者：
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