Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary study.
Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary study.
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DOI：
10.1016/j.nbas.2022.100059
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Dotson, Vonetta M.
中科院分区：
文献类型：
--
作者：
Gradone, Andrew M.;Champion, Gabriell;Mcgregor, Keith M.;Nocera, Joe R.;Barber, Sarah J.;Krishnamurthy, Lisa C.;Dotson, Vonetta M.
关键词：
阈值以下抑郁症状在老年人中非常普遍，并与许多健康风险有关，包括认知能力下降和身体健康下降。抑郁症的神经解剖学模型的中心脑区之一是前扣带回皮质(ACC)。ACC的吻侧部分--由先天的ACC和亚遗传的ACC组成--与情绪控制和奖赏加工有关。目前这项研究的目标是在28名居住在社区的老年人的种族多样性样本中，检查头端ACC亚区域的功能连接如何与抑郁症状有关，这是通过贝克抑郁清单第二版测量的。基于对以年轻人为主的临床抑郁症患者的先前研究的荟萃分析，我们假设，更严重的抑郁症状将主要与从亚膝部和前部到默认模式网络区域和背侧PFC的静息状态功能连接增加有关。相反，我们发现更高的抑郁症状与ACC到PFC背外侧和默认模式网络中的区域的功能连接性降低有关，包括从膝下ACC到PFC背外侧和前扣带回，以及从前ACC到扣带回中部。这项初步研究强调了老年人抑郁症状在阈值以下水平的大脑变化，这可能是干预的目标。
Subthreshold depressive symptoms are highly prevalent among older adults and are associated with numerous health risks including cognitive decline and decreased physical health. One brain region central to neuroanatomical models of depressive disorders is the anterior cingulate cortex (ACC). The rostral portion of the ACC—comprised of the pregenual ACC and subgenual ACC—is implicated in emotion control and reward processing. The goal of the current study was to examine how functional connectivity in subregions of the rostral ACC relate to depressive symptoms, measured by the Beck Depression Inventory-Second Edition, in an ethnically diverse sample of 28 community-dwelling older adults. Based on meta-analyses of previous studies in primarily young adults with clinical depression, we hypothesized that greater depressive symptoms would be associated with primarily increased resting-state functional connectivity from both the subgenual ACC and pregenual ACC to default mode network regions and the dorsolateral PFC. We instead found that higher depressive symptoms were associated with lower functional connectivity of the ACC to the dorsolateral PFC and regions within the default mode network, including from the subgenual ACC to the dorsolateral PFC and anterior cingulate and from the pregenual ACC to the middle cingulate gyrus. This preliminary study highlights brain alterations at subthreshold levels of depressive symptoms in older adults, which could serve as targets for interventions.
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影响因子：
25.8
作者：
Kaiser, Roselinde H.;Andrews-Hanna, Jessica R.;Wager, Tor D.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C
DOI：
10.1016/j.bpsc.2018.09.003
发表时间：
2019-03
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
--
作者：
Gandelman JA;Albert K;Boyd BD;Park JW;Riddle M;Woodward ND;Kang H;Landman BA;Taylor WD
通讯作者：
Taylor WD
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF