Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC.
Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC.
复制标题
鼻咽癌中肿瘤抑制/易感基因介导的信号转导网络。
DOI：
10.2174/138920209788488481
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发表时间：
2009-06
期刊：
影响因子：
2.6
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Wu M;Li X;Li X;Li G
鼻咽癌是一种多基因遗传病。SPLUNC 1、UBAP 1、BRD 7、NAG 7、NOR 1、NGX 6和LTF基因在鼻咽癌的不同阶段是抑癌/易感基因。SPLUNC 1是一种早期预警分子诊断标记物，抑制细菌克隆形成，是一种天然免疫分子。SPLUNC 1可通过负调控ERK/MAPK信号转导通路抑制鼻咽癌细胞增殖并诱导凋亡。BRD 7是一种转录调控因子，与BRD 2相互作用，促进BRD 2诱导的细胞凋亡。其启动子受c-Myc和SP1的调控。BRD 7通过抑制ras/MEK/ERK、Rb/E2 F和Wnt信号通路抑制NPC细胞周期进程，阻止通过G 0/G1。BRD 7的异常激活是鼻咽癌细胞周期紊乱的关键。NGX 6是一种转移相关蛋白，可负调控EGF/Ras/MAPK信号转导通路，并与ezrin蛋白相互作用，抑制鼻咽癌细胞的侵袭和转移。LTF也是一种转移相关蛋白，可负性调节MAPK信号转导通路，如JNK 2和ERK，从而抑制NPC细胞的增殖和生长。这些抑癌/易感基因可以调控ras/MEK/ERK、Rb/E2 F和EGFR ras/MEK/MAPK等细胞信号通路中的关键分子，也可以调控ezrin、nm 23和α-catenin等粘附分子的表达。根据功能基因组学和信号转导通路，我们已经描述了一个信号转导网络之间的肿瘤抑制/易感基因参与鼻咽癌。这些抑癌/易感基因可能成为鼻咽癌治疗的潜在靶点。
Nasopharyngeal carcinoma (NPC) is a polygenetic disease. SPLUNC1, UBAP1, BRD7, NAG7, NOR1, NGX6 and LTF genes were found to be tumor suppressor/susceptibility genes in different stages of NPC. SPLUNC1, an early warning molecular diagnosis marker, inhibits the bacteria clone formation, and is an innated immune molecule. SPLUNC1 can negatively regulate the ERK/MAPK signaling transduction pathway to inhibit NPC cell proliferation and induce apoptosis. BRD7, a transcript regulation factor, interacts with BRD2, and promotes apoptosis induced by BRD2. Its promoter is regulated by c-Myc and SP1. BRD7 inhibits NPC cell cycle progression, preventing passage through G0/G1 by suppressing ras/MEK/ERK, Rb/E2F and Wnt signaling pathways. Abnormal activation of BRD7 is crucial to cell cycle turbulence in NPC. NGX6, a metastasis-associated protein, can negative-regulate the EGF/Ras/MAPK signaling transduction pathway, and interacts with ezrin protein to inhibit NPC cell invasion and metastasis. LTF, also a metastasis-associated protein, can negatively regulate MAPK signal transduction pathways, such as JNK2 and ERK, to inhibit NPC cell proliferation and growth. Taken together, it was found that these tumor suppressor/susceptibility genes can regulate key molecules involved in cell signal pathways such as ras/MEK/ERK, Rb/E2F and EGFR ras/MEK/MAPK, and can regulate the expression of some adhesion molecules such as ezrin, nm23 and α-catenin. According to functional genomics and signaling transduction pathways, we have described a signaling cross-talk network between the tumor suppressor/susceptibility genes involved in NPC. These tumor suppressor/susceptibility genes may be potential treatment targets for NPC in the future.
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DOI：
10.1002/hed.20833
发表时间：
2008-07
影响因子：
2.9
作者：
Chou, Josephine;Lin, Yu-Ching;Kim, Jae;You, Liang;Xu, Zhidong;He, Biao;Jablons, David M.
通讯作者：
Jablons, David M.
影响因子：
9.7
作者：
Lo, Paulisally Hau Yi;Xie, Dan;Lung, Maria Li
通讯作者：
Lung, Maria Li
影响因子：
30.8
作者：
Feng, BJ;Huang, W;Zeng, YX
通讯作者：
Zeng, YX
影响因子：
4.7
作者：
Davidson, Ben;Konstantinovsky, Sophya;Reich, Reuven
通讯作者：
Reich, Reuven
启动子甲基化抑制人鼻咽癌细胞中 BRD7 的表达。
影响因子：
3.8
作者：
Liu H;Zhang L;Niu Z;Zhou M;Peng C;Li X;Deng T;Shi L;Tan Y;Li G
通讯作者：
Li G