Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly.
Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly.
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化学修饰的核酸和DNA嵌入剂作为纳米颗粒组装的工具。
DOI：
10.1039/d1cs00632k
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发表时间：
2021-11-29
影响因子：
46.2
通讯作者：
Kanaras AG
中科院分区：
文献类型：
--
作者：
De Fazio AF;Misatziou D;Baker YR;Muskens OL;Brown T;Kanaras AG
无机纳米颗粒自组装成更大的结构是非常有研究意义的，因为它可以制造出具有与纳米颗粒个体特性相关的集体性质的新型材料。最近开发的控制纳米颗粒组织的方法使一系列新材料的制造成为可能。其中，利用DNA组装纳米颗粒受到了人们的广泛关注，因为DNA在互补DNA链之间的高度选择性识别，DNA纳米结构的多功能性，以及DNA化学修饰的简便性。在这篇综述中，我们讨论了各种DNA化学修饰和分子嵌入剂作为操纵DNA纳米颗粒结构的工具的应用。详细讨论了DNA修饰和小分子插层剂在纳米结构的化学和光化学DNA连接中的应用；与可重构纳米颗粒组装相关的DNA轮烷和链烷；以及DNA骨架修饰，包括锁定核酸、肽核酸和硼烷核酸，它们影响复杂环境中纳米结构的稳定性。最后，我们强调了最大限度地发挥DNA化学和纳米粒子自组装之间的协同作用的重要性，目的是丰富可用于操纵纳米结构的工具库。DNA的化学操作为调整纳米粒子自组装的性质提供了新的工具。
The self-assembly of inorganic nanoparticles to larger structures is of great research interest as it allows the fabrication of novel materials with collective properties correlated to the nanoparticles’ individual characteristics. Recently developed methods for controlling nanoparticle organisation have enabled the fabrication of a range of new materials. Amongst these, the assembly of nanoparticles using DNA has attracted significant attention due to the highly selective recognition between complementary DNA strands, DNA nanostructure versatility, and ease of DNA chemical modification. In this review we discuss the application of various chemical DNA modifications and molecular intercalators as tools for the manipulation of DNA-nanoparticle structures. In detail, we discuss how DNA modifications and small molecule intercalators have been employed in the chemical and photochemical DNA ligation in nanostructures; DNA rotaxanes and catenanes associated with reconfigurable nanoparticle assemblies; and DNA backbone modifications including locked nucleic acids, peptide nucleic acids and borane nucleic acids, which affect the stability of nanostructures in complex environments. We conclude by highlighting the importance of maximising the synergy between the communities of DNA chemistry and nanoparticle self-assembly with the aim to enrich the library of tools available for the manipulation of nanostructures. The chemical manipulation of DNA offers new tools to tune the properties of nanoparticle self assemblies.
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影响因子：
15
作者：
Chakrabarti, R;Klibanov, AM
通讯作者：
Klibanov, AM
影响因子：
4.7
作者：
Kleinbaum, Daniel J.;Miller, Gregory P.;Kool, Eric T.
通讯作者：
Kool, Eric T.
影响因子：
10.8
作者：
Bayrak, Tuerkan;Helmi, Seham;Seidel, Ralf
通讯作者：
Seidel, Ralf
影响因子：
--
作者：
Baranov, Dmitry;Manna, Liberato;Kanaras, Antonios G.
通讯作者：
Kanaras, Antonios G.
影响因子：
8.4
作者：
Adhikari, Laxmi;Larm, Nathaniel E.;Baker, Gary A.
通讯作者：
Baker, Gary A.