Repetitive TMS suggests a role of the human dorsal premotor cortex in action prediction.
Repetitive TMS suggests a role of the human dorsal premotor cortex in action prediction.
复制标题
DOI：
10.3389/fnhum.2012.00020
复制
发表时间：
2012
影响因子：
2.9
通讯作者：
Prinz W
中科院分区：
文献类型：
--
作者：
Stadler W;Ott DV;Springer A;Schubotz RI;Schütz-Bosbach S;Prinz W
预测他人的行为对我们的日常交往至关重要。最近的证据表明，预测物体定向手臂和全身动作使用背侧运动前皮层（PMd）。因此，参与动作控制的神经基质也可能对动作预测至关重要。在这里，我们旨在解决这个问题，并假设破坏PMd会损害动作预测。使用fmri引导的线圈导航，rTMS（5个脉冲，10 Hz）应用于左侧PMd和顶点（控制区），同时参与者观察视频片段中的日常动作，这些视频片段被短暂遮挡了15秒。参与者在遮挡动作的时间过程中检测到操作，这需要他们在内部预测遮挡期间的动作。为了区分PMd在预测中可能发挥的功能作用，rTMS要么在咬合开始时（TMS-early）提供，影响动作预测的开始，要么在咬合期间（TMS-late）提供300 ms，影响持续预测的维持。TMS-early在左侧PMd上比TMS-early在顶点上产生更多的预测误差。TMS-late对预测性能没有影响，这表明左侧PMd可能特别参与内部引导动作预测的启动，但可能在维持持续预测中起次要作用。这些发现为左PMd在动作预测中的作用及其在动作控制和认知任务中的功能开辟了新的视角。在讨论中，强调了左PMd集成外部动作参数与观察者运动表的相关性。总的来说，结果与运动前功能在动作控制和动作观察中都有作用的观点是一致的。
Predicting the actions of other individuals is crucial for our daily interactions. Recent evidence suggests that the prediction of object-directed arm and full-body actions employs the dorsal premotor cortex (PMd). Thus, the neural substrate involved in action control may also be essential for action prediction. Here, we aimed to address this issue and hypothesized that disrupting the PMd impairs action prediction. Using fMRI-guided coil navigation, rTMS (five pulses, 10 Hz) was applied over the left PMd and over the vertex (control region) while participants observed everyday actions in video clips that were transiently occluded for 1 s. The participants detected manipulations in the time course of occluded actions, which required them to internally predict the actions during occlusion. To differentiate between functional roles that the PMd could play in prediction, rTMS was either delivered at occluder-onset (TMS-early), affecting the initiation of action prediction, or 300 ms later during occlusion (TMS-late), affecting the maintenance of an ongoing prediction. TMS-early over the left PMd produced more prediction errors than TMS-early over the vertex. TMS-late had no effect on prediction performance, suggesting that the left PMd might be involved particularly during the initiation of internally guided action prediction but may play a subordinate role in maintaining ongoing prediction. These findings open a new perspective on the role of the left PMd in action prediction which is in line with its functions in action control and in cognitive tasks. In the discussion, the relevance of the left PMd for integrating external action parameters with the observer’s motor repertoire is emphasized. Overall, the results are in line with the notion that premotor functions are employed in both action control and action observation.
登录
查看更多内容
DOI：
10.1098/rstb.2007.2054
发表时间：
2007-09-29
影响因子：
6.3
作者：
Cisek, Paul
通讯作者：
Cisek, Paul
外部和内部提示之间的区分：fMRI研究将跟踪与图形进行比较。
影响因子：
5.7
作者：
Gowen E;Miall RC
通讯作者：
Miall RC
影响因子：
2
作者：
Candidi, Matteo;Urgesi, Cosimo;Aglioti, Salvatore M.
通讯作者：
Aglioti, Salvatore M.
影响因子：
5.3
作者：
Abe, Mitsunari;Hanakawa, Takashi;Fukuyama, Hidenao
通讯作者：
Fukuyama, Hidenao
影响因子：
7.8
作者：
Fagg, AH;Arbib, MA
通讯作者：
Arbib, MA