Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.
Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.
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有证据表明，ITPR2 介导的少突胶质细胞内钙释放可调节碳酸酐酶 II I/II 型少突胶质细胞的发育和髓磷脂纤维的大小。
DOI：
10.3389/fncel.2021.751439
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发表时间：
2021
影响因子：
5.3
通讯作者：
Qiu M
中科院分区：
文献类型：
--
作者：
Mei R;Huang L;Wu M;Jiang C;Yang A;Tao H;Zheng K;Yang J;Shen W;Chen X;Zhao X;Qiu M
在中枢神经系统（CNS）中，少突胶质细胞（OL）对神经元轴突的髓鞘化使得能够实现快速跳跃传导和轴突完整性，这对于正常脑功能至关重要。以前的研究表明，不同亚型的少突胶质细胞在中枢神经系统形成不同类型的髓鞘决定的轴突的直径在单位。然而，不同类型的少突胶质细胞与不同纤维大小的发育相关的分子机制仍然难以捉摸。在本研究中，我们提出的证据表明，细胞内钙释放通道相关受体（Itpr 2）有助于这一发展过程。在早期发育过程中，Itpr 2在少突胶质细胞中选择性上调，与髓鞘形成的起始一致。在常规和条件Itpr 2突变小鼠的功能分析表明，Itpr 2缺陷导致OL分化的发育延迟，导致CAII+ I/II型OL的百分比增加，其更喜欢在CNS中髓鞘化小直径轴突。小口径有髓轴突比例的增加导致视神经复合动作电位（CAP）异常。总之，这些发现揭示了Itpr 2介导的钙信号在调节不同类型少突胶质细胞发育中的先前未被认识的作用。
Myelination of neuronal axons in the central nervous system (CNS) by oligodendrocytes (OLs) enables rapid saltatory conductance and axonal integrity, which are crucial for normal brain functioning. Previous studies suggested that different subtypes of oligodendrocytes in the CNS form different types of myelin determined by the diameter of axons in the unit. However, the molecular mechanisms underlying the developmental association of different types of oligodendrocytes with different fiber sizes remain elusive. In the present study, we present the evidence that the intracellular Ca2+ release channel associated receptor (Itpr2) contributes to this developmental process. During early development, Itpr2 is selectively up-regulated in oligodendrocytes coinciding with the initiation of myelination. Functional analyses in both conventional and conditional Itpr2 mutant mice revealed that Itpr2 deficiency causes a developmental delay of OL differentiation, resulting in an increased percentage of CAII+ type I/II OLs which prefer to myelinate small-diameter axons in the CNS. The increased percentage of small caliber myelinated axons leads to an abnormal compound action potentials (CAP) in the optic nerves. Together, these findings revealed a previously unrecognized role for Itpr2-mediated calcium signaling in regulating the development of different types of oligodendrocytes.
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影响因子：
30.8
作者：
Lappe-Siefke, C;Goebbels, S;Nave, KA
通讯作者：
Nave, KA
影响因子：
3.3
作者：
Franco-Pons, N.;Virgos, C.;Vilella, E.
通讯作者：
Vilella, E.
影响因子：
2.4
作者：
Korrell, Kim V.;Disser, Jolande;Hoerder-Suabedissen, Anna
通讯作者：
Hoerder-Suabedissen, Anna
影响因子：
6.2
作者：
Cai, Jun;Zhu, Qiang;Zheng, Kang;Li, Hong;Qi, Yingchuan;Cao, Qilin;Qiu, Mengsheng
通讯作者：
Qiu, Mengsheng
影响因子：
64.5
作者：
Emery B;Agalliu D;Cahoy JD;Watkins TA;Dugas JC;Mulinyawe SB;Ibrahim A;Ligon KL;Rowitch DH;Barres BA
通讯作者：
Barres BA