Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes.
Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes.
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DOI：
10.1002/glia.20937
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发表时间：
2010-03
期刊：
影响因子：
6.2
通讯作者：
Qiu, Mengsheng
中科院分区：
文献类型：
--
作者：
Cai, Jun;Zhu, Qiang;Zheng, Kang;Li, Hong;Qi, Yingchuan;Cao, Qilin;Qiu, Mengsheng
最近的研究表明，Nkx6.2/Gtx 和 Nkx2.2 同源域转录因子参与主要发生在出生后阶段的少突胶质细胞成熟和/或髓鞘形成的调节。然而，它们在出生后中枢神经系统中的细胞特异性尚未得到表征，并且它们在少突胶质细胞谱系进展过程中的动态表达关系尚未确定。在这里，我们报道 Nkx2.2 和 Nkx6.2 在出生后脊髓少突胶质细胞谱系的 Olig2+ 细胞中选择性表达。 Nkx6.2 在 APC+ 成熟少突胶质细胞中特异性表达，而 Nkx2.2 最初在分化的少突胶质细胞前体细胞 (OPC) 中表达，但随着 OPC 进行终末分化，其表达迅速下调。有趣的是，Nkx2.2 表达在成熟髓鞘少突胶质细胞的后期阶段上调。 Nkx2.2 和 Nkx6.2 转录因子在髓鞘少突胶质细胞中的共表达表明它们在调节髓鞘形成和/或维持中的功能相互作用。
Recent studies have suggested that Nkx6.2/Gtx and Nkx2.2 homeodomain transcription factors are involved in the regulation of oligodendrocyte maturation and/or myelination which occur predominantly in postnatal stages. However, their cellular specificity in postnatal central nervous system has not been characterized and their dynamic expressional relationship during oligodendrocyte lineage progression has not been determined. Here we report that both Nkx2.2 and Nkx6.2 are selectively expressed in Olig2+ cells of oligodendrocyte lineage in postnatal spinal cords. While Nkx6.2 is specifically expressed in the APC+ mature oligodendrocytes, Nkx2.2 is initially expressed in differentiating oligodendrocyte precursor cells (OPCs) but quickly down-regulated as OPCs undergo terminal differentiation. Intriguingly, Nkx2.2 expression is up-regulated in mature myelinating oligodendrocytes at later stages. The co-expression of Nkx2.2 and Nkx6.2 transcription factors in myelinating oligodendrocytes suggests their functional interactions in the regulation of myelin sheath formation and/or maintenance.
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影响因子：
16.2
作者：
Lu, QR;Yuk, DI;Rowitch, DH
通讯作者：
Rowitch, DH
DOI：
10.1083/jcb.85.3.890
发表时间：
1980-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
McCarthy KD;de Vellis J
通讯作者：
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影响因子：
16.2
作者：
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通讯作者：
Anderson, DJ
影响因子：
10.5
作者：
Stolt, CC;Rehberg, S;Wegner, M
通讯作者：
Wegner, M
影响因子：
5.2
作者：
Cheng, Xiaoxin;Wang, Yaping;Cao, Qilin
通讯作者：
Cao, Qilin