The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice.
The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice.
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DOI：
10.1038/s41431-021-01000-x
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发表时间：
2022-05
影响因子：
5.2
通讯作者：
Genuardi, Maurizio
中科院分区：
文献类型：
--
作者：
Forzano, Francesca;Antonova, Olga;Clarke, Angus;de Wert, Guido;Hentze, Sabine;Jamshidi, Yalda;Moreau, Yves;Perola, Markus;Prokopenko, Inga;Read, Andrew;Reymond, Alexandre;Stefansdottir, Vigdis;van El, Carla;Genuardi, Maurizio
一些私人检测公司正在向使用体外受精的父母推销胚胎多基因风险评分分析（PGT-P），因为它有助于选择在以后的生活中患病风险最小的胚胎。似乎至少有一个孩子是在这种手术后出生的。但是，PRS在这方面的实用性受到严重限制，迄今为止，还没有进行临床研究来评估其在胚胎中的诊断有效性。患者需要适当地了解这种使用PRS的局限性，并且在该人群中进一步实施该技术之前，应该进行一场社会辩论，重点是在选择个体特征方面被认为是可接受的。
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.
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DOI：
10.1038/s41436-018-0058-9
发表时间：
2019-03
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Martens FK;Tonk ECM;Janssens ACJW
通讯作者：
Janssens ACJW
影响因子：
64.8
作者：
Wand H;Lambert SA;Tamburro C;Iacocca MA;O'Sullivan JW;Sillari C;Kullo IJ;Rowley R;Dron JS;Brockman D;Venner E;McCarthy MI;Antoniou AC;Easton DF;Hegele RA;Khera AV;Chatterjee N;Kooperberg C;Edwards K;Vlessis K;Kinnear K;Danesh JN;Parkinson H;Ramos EM;Roberts MC;Ormond KE;Khoury MJ;Janssens ACJW;Goddard KAB;Kraft P;MacArthur JAL;Inouye M;Wojcik GL
通讯作者：
Wojcik GL
DOI：
10.1056/nejmsr2105065
发表时间：
2021-07-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Turley P;Meyer MN;Wang N;Cesarini D;Hammonds E;Martin AR;Neale BM;Rehm HL;Wilkins-Haug L;Benjamin DJ;Hyman S;Laibson D;Visscher PM
通讯作者：
Visscher PM
影响因子：
2.7
作者：
Pagnaer T;Siermann M;Borry P;Tšuiko O
通讯作者：
Tšuiko O