Memory and the circadian system: Identifying candidate mechanisms by which local clocks in the brain may regulate synaptic plasticity.

Memory and the circadian system: Identifying candidate mechanisms by which local clocks in the brain may regulate synaptic plasticity.
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记忆与昼夜节律系统:识别候选机制,通过这些机制,大脑中的本地时钟可以调节突触可塑性。

DOI:
10.1016/j.neubiorev.2020.07.023
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发表时间:
2020-11
影响因子:
8.2
通讯作者:
Spencer RL
Spencer RL
中科院分区:
医学1区
文献类型:
--
作者:
Hartsock MJ;Spencer RL

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昼夜节律系统是一种内源性生物网络,负责协调行为和生理学中的近24小时周期与来自外部环境的每日定时提示。在这篇综述中,我们探讨了昼夜节律系统如何调节记忆的形成,保持和回忆。这些记忆过程中的昼夜节律可能通过几种内源性途径产生,最近的工作突出了在组织中发现的遗传计时器的重要性,称为本地时钟。我们评估了昼夜节律记忆文献中的证据,当地时钟参与记忆,识别潜在的节点之间的直接相互作用的本地时钟组件和突触可塑性的机制。我们的讨论说明了当地的时钟可能普遍调节神经元的可塑性的能力,我们在这里指定为昼夜节律metaplasticity的现象。我们认为,这种功能的本地时钟支持的时间优化的记忆过程,照亮了潜在的昼夜节律的治疗策略,在预防和治疗记忆障碍。
The circadian system is an endogenous biological network responsible for coordinating near-24-hour cycles in behavior and physiology with daily timing cues from the external environment. In this review, we explore how the circadian system regulates memory formation, retention, and recall. Circadian rhythms in these memory processes may arise through several endogenous pathways, and recent work highlights the importance of genetic timekeepers found locally within tissues, called local clocks. We evaluate the circadian memory literature for evidence of local clock involvement in memory, identifying potential nodes for direct interactions between local clock components and mechanisms of synaptic plasticity. Our discussion illustrates how local clocks may pervasively modulate neuronal plastic capacity, a phenomenon that we designate here as circadian metaplasticity. We suggest that this function of local clocks supports the temporal optimization of memory processes, illuminating the potential for circadian therapeutic strategies in the prevention and treatment of memory impairment.
从分子到全脑网络的睡眠,可塑性和记忆力。
DOI: 10.1016/j.cub.2013.07.025
发表时间: 2013-09-09
期刊: CURRENT BIOLOGY
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Abel, Ted;Havekes, Robbert;Saletin, Jared M.;Walker, Matthew P.
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昼夜节律的代谢和能量学的融合。
DOI: 10.1126/science.1195027
发表时间: 2010-12-03
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Bass J;Takahashi JS
通讯作者: Takahashi JS