Review of Stratum Corneum Impedance Measurement in Non-Invasive Penetration Application.
Review of Stratum Corneum Impedance Measurement in Non-Invasive Penetration Application.
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DOI：
10.3390/bios8020031
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发表时间：
2018-03-26
期刊：
影响因子：
--
通讯作者：
Zhao Z
中科院分区：
文献类型：
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作者：
Lu F;Wang C;Zhao R;Du L;Fang Z;Guo X;Zhao Z
由于远程医疗、移动的医疗保健、可穿戴健康监测和电子皮肤的进步，已经针对疾病的非侵入性监测和治疗做出了很大努力。这些过程通常涉及从间质液（ISF）而不是血液进行疾病检测，以及透皮药物递送。然而，ISF的定量提取和药物吸收水平受个体皮肤渗透性的极大影响，这与角质层（SC）的性质密切相关。因此，SC阻抗的测量已被提议作为评估个体皮肤差异的适当方式。为了了解人体皮肤电阻抗检测的现状和研究方向，本文对皮肤电阻抗检测的研究进行了综述。在回顾了阻抗模型、电极、测量方法和系统及其在治疗中的应用后，总结了未来的发展方向。相信在不久的将来，将建立良好匹配的皮肤阻抗模型和测量方法，用于临床和护理点应用。
Due to advances in telemedicine, mobile medical care, wearable health monitoring, and electronic skin, great efforts have been directed to non-invasive monitoring and treatment of disease. These processes generally involve disease detection from interstitial fluid (ISF) instead of blood, and transdermal drug delivery. However, the quantitative extraction of ISF and the level of drug absorption are greatly affected by the individual’s skin permeability, which is closely related to the properties of the stratum corneum (SC). Therefore, measurement of SC impedance has been proposed as an appropriate way for assessing individual skin differences. In order to figure out the current status and research direction of human SC impedance detection, investigations regarding skin impedance measurement have been reviewed in this paper. Future directions are concluded after a review of impedance models, electrodes, measurement methods and systems, and their applications in treatment. It is believed that a well-matched skin impedance model and measurement method will be established for clinical and point-of care applications in the near future.
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影响因子：
10.3
作者：
BLAIR, C
通讯作者：
BLAIR, C
影响因子：
5.6
作者：
Clemente, Fabrizio;Romano, Maria;Cesarelli, Mario
通讯作者：
Cesarelli, Mario
影响因子：
10.8
作者：
Dujardin, N;Staes, E;Préat, V
通讯作者：
Préat, V
影响因子：
3.5
作者：
Huclova, Sonja;Baumann, Dirk;Froehlich, Juerg
通讯作者：
Froehlich, Juerg
DOI：
10.1083/jcb.65.1.180
发表时间：
1975-04
期刊：
The Journal of cell biology
影响因子：
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作者：
通讯作者：
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