Genetic variation across C-reactive protein and risk of prostate cancer.
Genetic variation across C-reactive protein and risk of prostate cancer.
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C反应性蛋白质和前列腺癌风险之间的遗传变异。
DOI：
10.1002/pros.22820
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发表时间：
2014-07
期刊：
影响因子：
2.8
通讯作者：
Mucci, Lorelei A.
中科院分区：
文献类型：
--
作者：
Markt, Sarah C.;Rider, Jennifer R.;Penney, Kathryn L.;Schumacher, Fredrick R.;Epstein, Mara M.;Fall, Katja;Sesso, Howard D.;Stampfer, Meir J.;Mucci, Lorelei A.
炎症已被假设为在前列腺癌的发生或进展中起重要的病因作用。全身炎症标志物C反应蛋白（CRP）的循环水平与前列腺癌风险增加有关。我们研究了CRP和前列腺癌中遗传变异的作用，假设变异可能改变疾病的风险。我们在1,286名前列腺癌患者和1,264名对照者中进行了一项前瞻性医生健康研究中的病例对照研究。选择四种单核苷酸多态性（SNP）来捕获CRP中常见的遗传变异（r2> 0.8）。我们使用非条件logistic回归来评估每个SNP与前列腺癌风险之间的关联。线性回归模型探讨了每个基因型和血浆CRP水平之间的关联。没有CRP SNP与前列腺癌总体相关。在rs1800947中有一个次要等位基因（C）拷贝的个体患高级别前列腺癌的风险增加（OR：1.7; 95% CI：1.1 - 2.8），平均CRP水平显著降低（p值<0.001），然而，我们发现与致死性疾病无显著相关性。在rs3093075和rs1417939中具有一个或两个次要等位基因拷贝的男性中，平均CRP水平显著升高，但这些与前列腺癌风险无关。我们的研究结果表明，CRP基因中的SNPs与总体或致死性前列腺癌的风险无关。CRP rs1800947的多态性可能与更高级别的疾病相关，但我们的结果需要在其他队列中重复。
Inflammation has been hypothesized to play an important etiological role in the initiation or progression of prostate cancer. Circulating levels of the systemic inflammation marker C-reactive protein (CRP) have been associated with increased risk of prostate cancer. We investigated the role of genetic variation in CRP and prostate cancer, under the hypothesis that variants may alter risk of disease. We undertook a case-control study nested within the prospective Physicians' Health Study among 1,286 men with incident prostate cancer and 1,264 controls. Four single-nucleotide polymorphisms (SNPs) were selected to capture the common genetic variation across CRP (r2>0.8). We used unconditional logistic regression to assess the association between each SNP and risk of prostate cancer. Linear regression models explored associations between each genotype and plasma CRP levels. None of the CRP SNPs were associated with prostate cancer overall. Individuals with one copy of the minor allele (C) in rs1800947 had an increased risk of high-grade prostate cancer (OR: 1.7; 95% CI: 1.1–2.8), and significantly lower mean CRP levels (p-value <0.001), however, we found no significant association with lethal disease. Mean CRP levels were significantly elevated in men with one or two copies of the minor allele in rs3093075 and rs1417939, but these were unrelated to prostate cancer risk. Our findings suggest that SNPs in the CRP gene are not associated with risk of overall or lethal prostate cancer. Polymorphisms in CRP rs1800947 may be associated with higher grade disease, but our results require replication in other cohorts.
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影响因子：
2.3
作者：
Platz, Elizabeth A.;Sutcliffe, Siobhan;De Marzo, Angelo M.;Drake, Charles G.;Rifai, Nader;Hsing, Ann W.;Hoque, Ashraful;Neuhouser, Marian L.;Goodman, Phyllis J.;Kristal, Alan R.
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通讯作者：
Ringelstein, E. Bernd
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9.8
作者：
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通讯作者：
Lin, Xihong
影响因子：
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作者：
Pepys, MB;Hirschfield, GM
通讯作者：
Hirschfield, GM