Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival.
Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival.
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C反应蛋白的基因变异与结肠癌和直肠癌风险及生存的关系
DOI：
10.1002/ijc.25721
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发表时间：
2011-06-01
影响因子：
6.4
通讯作者：
Ulrich, Cornelia M.
中科院分区：
文献类型：
--
作者：
Slattery, Martha L.;Curtin, Karen;Poole, Elizabeth M.;Duggan, David J.;Samowitz, Wade S.;Peters, Ulrike;Caan, Bette J.;Potter, John D.;Ulrich, Cornelia M.
关键词：
C-反应蛋白（CRP）是炎症的生物标志物，已被证明受CRP基因遗传变异的影响。在这项研究中，我们检验了CRP基因变异影响结肠癌和直肠癌发病风险和生存率的假设。进行了两项基于人群的结肠癌（n=1574例，1970例对照）和直肠癌（n=791例，999例对照）研究。我们评估了四种CRP tagSNPs：rs 1205（G>A，3' UTR）; rs 1417938（T>A，内含子）; rs 1800947（G>C，L184 L）;和rs3093075（C>A，3'侧翼）。CRP rs 1205 AA基因型与结肠癌风险增加相关（OR 1.3，95%CI 1.1-1.7），而rs3093075 A等位基因与直肠癌风险降低相关（OR 0.7，95%CI 0.5-0.9）。rs 1205多态性与结肠癌的最强关联在KRAS 2突变的患者中观察到（OR 1.5，95%CI 1.1-2.0）。CRP rs 1205 AA基因型也与CIMP+直肠肿瘤风险增加相关（OR 2.5，95%CI 1.2-5.3）;相反，rs 1417938 A等位基因与CIMP+直肠肿瘤风险降低相关（OR 0.5，95%CI 0.3-0.9）。我们观察了CRP rs 1800947和BMI以及CRC家族史在改变结肠癌和直肠癌风险方面的相互作用。这些数据表明，CRP基因的遗传变异影响结肠癌和直肠癌发生的风险。
C-reactive protein (CRP), a biomarker of inflammation has been shown to be influenced by genetic variation in the CRP gene. In this study, we test the hypothesis that genetic variation in CRP influences both the risk of developing colon and rectal cancer and survival. Two population-based studies of colon cancer (n=1574 cases, 1970 controls) and rectal (n=791 cases, 999 controls) were conducted. We evaluated four CRP tagSNPs: rs1205 (G>A, 3’ UTR); rs1417938 (T>A, intron); rs1800947 (G>C, L184L); and rs3093075 (C>A, 3’ flanking). The CRP rs1205 AA genotype was associated with an increased risk of colon cancer (OR 1.3, 95%CI 1.1-1.7), whereas the rs3093075 A allele was associated with a reduced risk of rectal cancer (OR 0.7, 95%CI 0.5-0.9). The strongest association for the rs1205 polymorphism and colon cancer was observed among those with KRAS2 mutations (OR 1.5, 95%CI 1.1-2.0). The CRP rs1205 AA genotype also was associated with an increased risk of CIMP+ rectal tumors (OR 2.5, 95% CI 1.2-5.3); conversely, the rs1417938 A allele was associated with a reduced risk of CIMP+ rectal tumors (OR 0.5, 95%CI 0.3-0.9). We observed interactions between CRP rs1800947 and BMI and family history of CRC in modifying risk of both colon and rectal cancer. These data suggest that genetic variation in the CRP gene influences risk of both colon and rectal cancer development.
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影响因子：
5.8
作者：
Hage, Fadi G.;Szalai, Alexander J.
通讯作者：
Szalai, Alexander J.
影响因子：
16.2
作者：
Shen, Jian;Arnett, Donna K.;Ordovas, Jose M.
通讯作者：
Ordovas, Jose M.
影响因子：
8.3
作者：
Schumacher, Wiebke;Cockcroft, John;Ben-Shlomo, Yoav
通讯作者：
Ben-Shlomo, Yoav
影响因子：
4.9
作者：
Eiriksdottir, G.;Smith, A. V.;Aspelund, T.;Hafsteinsdottir, S. H.;Olafsdottir, E.;Launer, L. J.;Harris, T. B.;Gudnason, V.
通讯作者：
Gudnason, V.
影响因子：
2.6
作者：
Poole EM;Bigler J;Whitton J;Sibert JG;Potter JD;Ulrich CM
通讯作者：
Ulrich CM