Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies.
Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies.
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DOI：
10.1007/s10552-010-9511-z
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发表时间：
2010-06
影响因子：
2.3
通讯作者：
Kristal, Alan R.
中科院分区：
文献类型：
--
作者：
Platz, Elizabeth A.;Sutcliffe, Siobhan;De Marzo, Angelo M.;Drake, Charles G.;Rifai, Nader;Hsing, Ann W.;Hoque, Ashraful;Neuhouser, Marian L.;Goodman, Phyllis J.;Kristal, Alan R.
在癌症和其他慢性疾病病因的前瞻性研究中，需要关于高敏感性c反应蛋白（hsCRP）的长期个体内变异性的数据来确定一种测量是否足以反映正常水平；如果不是反思性的，统计检测适度到中度关联的能力就会降低。作者估计了这一变异性来源的大小和相应的相对风险（RR）衰减。在前列腺癌预防试验（PCPT）安慰剂组的50名男性中，使用高灵敏度免疫浊度测定法在第2、4和6年收集的血清中测量hsCRP浓度。对hsCRP进行自然对数变换后，采用方差分析估计个体内部和个体之间的方差，由此计算类内相关系数（ICC）。由于ICC <1而观察到的RR由e（ln真RR*ICC）在真RR范围内计算。4年的ICC为0.66。测量一次hsCRP，假设没有其他误差，如果高、低浓度的真实RRs分别为1.50、2.00、3.00，则观察到的RRs分别为1.31、1.58、2.06。计划仅测量一次hsCRP的研究人员应设计足够规模的研究，以保留假设的中度至中度rr的推论。
Data on long-term intra-individual variability in high sensitivity C-reactive protein (hsCRP) are needed to determine whether one measurement adequately reflects usual levels in prospective studies of on the etiology of cancer and other chronic diseases; when not reflective, the ability to statistically detect modest to moderate associations is reduced. The authors estimated the size of this source of variability and consequent attenuation of the relative risk (RR). hsCRP concentration was measured using a high-sensitivity immunoturbidometric assay in sera collected at years 2, 4, and 6 from 50 men in the placebo arm of the Prostate Cancer Prevention Trial (PCPT). After natural logarithm-transformation of hsCRP, analysis of variance was used to estimate the within and between individual variances from which the intra-class correlation coefficient (ICC) was calculated. The observed RR due to an ICC <1 was calculated by e(ln true RR*ICC) for a range of true RRs. The four-year ICC was 0.66. Measuring hsCRP once and assuming no other error, if the true RRs were 1.50, 2.00, and 3.00 when comparing high with low concentration then the observed RRs would be 1.31, 1.58, and 2.06, respectively. Investigators planning to measure hsCRP only once should design adequately sized studies to preserve inferences for hypothesized modest to moderate RRs.
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影响因子：
2.2
作者：
CLARK, GH;FRASER, CG
通讯作者：
FRASER, CG
影响因子：
3.3
作者：
Nasermoaddeli, A;Sekine, M;Kagamimori, S
通讯作者：
Kagamimori, S
影响因子：
2.6
作者：
Al-Delaimy, W. K.;Jansen, E. H. J. M.;Beuno-De-Mesquita, H. B.
通讯作者：
Beuno-De-Mesquita, H. B.
影响因子：
158.5
作者：
Thompson, IM;Goodman, PJ;Coltman, CA
通讯作者：
Coltman, CA
影响因子：
5
作者：
Koenig, W;Sund, M;Pepys, MB
通讯作者：
Pepys, MB