Sociality predicts individual variation in the immunity of free-ranging rhesus macaques.
Sociality predicts individual variation in the immunity of free-ranging rhesus macaques.
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DOI：
10.1016/j.physbeh.2021.113560
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发表时间：
2021-11-01
影响因子：
2.9
通讯作者：
Brent LJN
中科院分区：
文献类型：
--
作者：
Pavez-Fox MA;Negron-Del Valle JE;Thompson IJ;Walker CS;Bauman SE;Gonzalez O;Compo N;Ruiz-Lambides A;Martinez MI;Cayo Biobank Research Unit;Platt ML;Montague MJ;Higham JP;Snyder-Mackler N;Brent LJN
社会融合和社会地位可对个人的健康和生存产生重大影响。发生这种情况的一种途径是改变免疫功能，这对社会环境的变化非常敏感。然而，我们目前对社会性如何影响自然主义人群中的免疫标志物的理解有限，在自然主义人群中，社会动态可以充分实现。为了解决这一差距，我们问社会融合和社会地位在自由放养的恒河猴（猕猴）预测免疫的解剖和生理标志物。我们使用的数据竞争的相互作用，以确定社会地位，和社会网络分析梳理的相互作用，以产生社会融合的个体差异的措施。作为免疫力的指标，我们包括参与免疫反应的两个主要器官（脾脏和肝脏）的大小，以及三种血细胞（红细胞、血小板和白色细胞）的计数。控制体重和年龄，我们发现社会地位和社会融合都不能预测免疫的解剖标志物的大小。然而，那些社会关系更密切的人，即，有更多梳理伴侣的人，其白色血细胞的数量比社交孤立的人要少，这表明随着融合水平的提高，炎症水平也会降低。这些结果建立在并扩展了我们对人类和圈养动物的社会性和免疫系统之间关系的认识，以自由放养的灵长类动物，证明了社会融合对健康的有益作用的普遍性。
Social integration and social status can substantially affect an individual’s health and survival. One route through which this occurs is by altering immune function, which can be highly sensitive to changes in the social environment. However, we currently have limited understanding of how sociality influences markers of immunity in naturalistic populations where social dynamics can be fully realized. To address this gap, we asked if social integration and social status in free-ranging rhesus macaques (Macaca mulatta) predict anatomical and physiological markers of immunity. We used data on agonistic interactions to determine social status, and social network analysis of grooming interactions to generate measures of individual variation in social integration. As measures of immunity, we included the size of two of the major organs involved in the immune response, the spleen and liver, and counts of three types of blood cells (red blood cells, platelets, and white blood cells). Controlling for body mass and age, we found that neither social status nor social integration predicted the size of anatomical markers of immunity. However, individuals that were more socially connected, i.e., with more grooming partners, had lower numbers of white blood cells than their socially isolated counterparts, indicating lower levels of inflammation with increasing levels of integration. These results build upon and extend our knowledge of the relationship between sociality and the immune system in humans and captive animals to free-ranging primates, demonstrating generalizability of the beneficial role of social integration on health.
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影响因子：
2.5
作者：
Balasubramaniam, Krishna N.;Beisner, Brianne A.;McCowan, Brenda
通讯作者：
McCowan, Brenda
DOI：
10.1098/rspb.2017.0515
发表时间：
2017-05-17
影响因子：
4.7
作者：
Brent, L. J. N.;Ruiz-Lambides, A.;Platt, M. L.
通讯作者：
Platt, M. L.
影响因子：
1.7
作者：
CHIKAZAWA D;GORDON T P;BERNSTEIN I S
通讯作者：
BERNSTEIN I S
影响因子：
15.8
作者：
Holt-Lunstad J;Smith TB;Layton JB
通讯作者：
Layton JB
影响因子：
3.9
作者：
Eisinger F;Patzelt J;Langer HF
通讯作者：
Langer HF