Structure control of hydroxyapatite ceramics via an electric field assisted freeze casting method

Structure control of hydroxyapatite ceramics via an electric field assisted freeze casting method
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电场辅助冷冻铸造法控制羟基磷灰石陶瓷的结构

DOI:
10.1016/j.ceramint.2015.03.069
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发表时间:
2015-08
影响因子:
5.2
通讯作者:
Z.P. Wu
Z.P. Wu
中科院分区:
材料科学1区
文献类型:
--
作者:
Z. Cheng;K. Zhao;Z.P. Wu

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以H2 O2水溶液为造孔剂,采用冷冻铸造法制备了具有层状和球形孔结构的羟基磷灰石(HA)多孔支架。使用体积分数为5%的H2 O2水溶液制备的HA支架孔隙率最高。研究了电场强度与HA支架性能的关系。结果表明,当电场强度从0增加到90 kV/m时,HA支架的片层孔和球形孔的平均直径分别从460 μm增加到810 μm和320 μ m增加到420 μm。体外细胞实验表明,具有层状和球形孔的HA支架比单一孔的HA支架具有更好的生物相容性。
Using H2O2aqueous solution as pore-forming agent, hydroxyapatite (HA) porous scaffolds with both lamellar and spherical pores were fabricated by a freeze casting method. The highest porosity was obtained in HA scaffolds prepared using 5 vol% H2O2aqueous solution. The relationship between the electric field intensity and the properties of HA scaffolds was investigated. Results showed that when the electric field intensity was increased from 0 to 90 kV/m, the average diameters of lamellar and spherical pores of HA scaffold were increased from 460 μm to 810 μm, and from 320 μm to 420 μm, respectively. Vitro cellular assay indicated that HA scaffold with both the lamellar and the spherical pores has a better biocompatibility, compared with that with single pores.
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