Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly.
Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly.
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DOI：
10.1038/s41598-017-14608-1
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发表时间：
2017-10-30
影响因子：
4.6
通讯作者：
Kume K
中科院分区：
文献类型：
--
作者：
Hasegawa T;Tomita J;Hashimoto R;Ueno T;Kume S;Kume K
饥饿会减少各种动物的睡眠，包括人类和果蝇。即时饥饿和随后由饥饿引起的营养不足可能会对睡眠和觉醒产生不同的影响。为了阐明饮食和睡眠之间关系的机制，我们分析了饥饿或喂食不同类型糖的果蝇的睡眠行为。饥饿的果蝇表现出较长的活动时间，较短的睡眠时间和较低的唤醒阈值。非营养甜味剂如三氯蔗糖和阿拉伯糖，它们是甜的但没有营养，诱导饥饿的苍蝇睡眠，但睡眠时间和唤醒阈值分别缩短和降低。另一方面，山梨糖醇，这是不甜，但营养，不诱导睡眠，但略有增加降低唤醒阈值。甜味受体表达神经元的激活诱导饥饿果蝇的睡眠。这些结果表明，单独的甜味足以诱导饥饿的果蝇睡眠，营养状况通过降低唤醒阈值影响睡眠稳态，这导致果蝇的短暂睡眠。
Starvation reduces sleep in various animal species including humans and fruit flies. Immediate hunger and the following insufficient nutritional status resulting from starvation may affect sleep and arousal differently. In order to clarify the mechanism underlying the relationship between diet and sleep, we analysed the sleep behaviour of Drosophila melanogaster that were either starved or fed with different types of sugars. Starved flies showed longer activity bouts, short sleep bouts and a decreased arousal threshold. Non-nutritive sweeteners such as sucralose and arabinose, which are sweet but not nutritive, induced sleep in starved flies, but sleep bout length and the arousal threshold was short and decreased, respectively. On the other hand, sorbitol, which is not sweet but nutritive, did not induce sleep, but slightly increased the lowered arousal threshold. Activation of sweetness receptor expressing neurons induced sleep in starved flies. These results suggest that sweetness alone is sufficient to induce sleep in starved flies and that the nutritional status affects sleep homeostasis by decreasing the arousal threshold, which resulted in short sleep bouts in Drosophila.
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影响因子：
64.5
作者：
Miyamoto T;Slone J;Song X;Amrein H
通讯作者：
Amrein H
影响因子：
5.6
作者：
Cong, Xiaona;Wang, Haili;Zhao, Zhangwu
通讯作者：
Zhao, Zhangwu
影响因子：
5.8
作者：
Copinschi, Georges;Nedeltcheva, Arlet;Van Cauter, Eve
通讯作者：
Van Cauter, Eve
DOI：
10.1073/pnas.1401501112
发表时间：
2015-02-24
影响因子：
11.1
作者：
Linford, Nancy J.;Ro, Jennifer;Pletcher, Scott D.
通讯作者：
Pletcher, Scott D.
DOI：
10.1111/nyas.12355
发表时间：
2014-01-01
期刊：
YEAR IN DIABETES AND OBESITY
影响因子：
--
作者：
Reutrakul, Sirimon;Van Cauter, Eve
通讯作者：
Van Cauter, Eve