Cortisol levels and depression in men and women using heroin and cocaine.
Cortisol levels and depression in men and women using heroin and cocaine.
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使用海洛因和可卡因的男性和女性的皮质醇水平和抑郁症。
DOI：
10.1016/j.psyneuen.2005.08.002
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发表时间：
2006
影响因子：
3.7
通讯作者：
Dobs,AdrianS
中科院分区：
文献类型：
--
作者：
Wisniewski,AmyB;Brown,ToddT;John,Majnu;CofrancesoJr,Joseph;Golub,ElizabethT;Ricketts,ErinP;Wand,Gary;Dobs,AdrianS
在使用非法药物和/或感染艾滋病毒的男性中，下丘脑-垂体-肾上腺 (HPA) 轴的异常已得到充分记录；然而，对于女性的 HPA 功能或 HPA 功能障碍对健康的影响，人们知之甚少。抑郁症患者会表现出高皮质醇血症，而抑郁症在艾滋病毒或药物滥用问题患者中很常见。目前的研究调查了 209 名人口统计匹配的男性和女性的皮质醇分泌情况，并根据他们的艾滋病毒和吸毒状况进行了分层。使用标准化、经过验证的问卷（CES-D）评估自我报告的抑郁症状。女性报告的抑郁症状多于男性 (p=.01)。与非吸毒者相比，男性和女性吸毒者表现出更高的皮质醇浓度 (p=.03)，并且更有可能报告抑郁症状 (p=.04)。研究人群的抑郁症与皮质醇浓度升高有关 (p=.03)，皮质醇浓度升高的女性比所有其他参与者显着更抑郁 (p=.05)。虽然尚不清楚高皮质醇浓度是否先于抑郁症状，或反之亦然，但这些数据表明，较高的皮质醇浓度与海洛因和可卡因使用者的抑郁症状相关，并且这种关联在女性中比男性更明显。在本研究中，HIV 状态与皮质醇或 CES-D 测量药物的使用并没有以相加或协同的方式发挥作用。治疗男性和女性非法药物使用造成的内分泌和心理健康后果的独特疗法值得考虑，因为抑郁症状以及与抑郁症状相关的高皮质醇浓度因性别而异。
Abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis are well documented in men using illicit drugs and/or infected with HIV; however, less is known about HPA function, or the health consequence of HPA dysfunction, in their female counterparts. People with depression exhibit hypercortisolemia, and depression is common in people with HIV or substance use problems. The current study investigated cortisol secretion in 209 demographically matched men and women, stratified by their HIV and drug use status. Self-reported depressive symptoms were evaluated using a standardized, validated questionnaire (CES-D). Women reported more depressive symptoms than men (p=.01). Male and female drug users exhibited higher cortisol concentrations (p=.03), and were more likely to report depressive symptoms (p=.04), than non-users. Depression was related to elevated cortisol concentrations for the study population (p=.03), and women with elevated cortisol concentrations were significantly more depressed than all other participants (p=.05). While it is unknown whether high cortisol concentrations precede depressive symptoms or vice versa, these data indicate that higher cortisol concentrations are associated with depressive symptoms in heroin and cocaine users, and that this association is more pronounced in women than men. HIV status did not act in an additive or synergistic way with drug use for either cortisol or CES-D measures in the current study. Unique therapies to treat the endocrine and mental health consequences of illicit drug use in men and women deserve consideration as depressive symptoms, and high cortisol concentrations associated with depressive symptoms, differ by gender.
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DOI：
--
发表时间：
1983
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Hojvat,SA;Musch,MW;Miller,RJ
通讯作者：
Miller,RJ
来自肠上皮的基底外侧和刷状缘质膜的碱性磷酸酶。
DOI：
10.1002/jss.400110404
发表时间：
1979
期刊：
Journal of supramolecular structure
影响因子：
--
作者：
S. Hanna;A. Mircheff;E. M. Wright
通讯作者：
E. M. Wright
影响因子：
2.9
作者：
HOLMQUIST, B;BUNNING, P;RIORDAN, JF
通讯作者：
RIORDAN, JF
肠神经元对肠离子转运的局部调节。
DOI：
10.1152/ajpgi.1983.244.5.g457
发表时间：
1983
期刊：
The American journal of physiology
影响因子：
--
作者：
E. Tapper
通讯作者：
E. Tapper
新型非巯基转化酶抑制剂2-[N-[(S)-1-乙氧基羰基-3-苯基丙基]-L-丙氨酰]-(1S,3S,5S)-2-氮杂双环[3.3]的心血管和抗高血压活性
DOI：
10.1097/00005344-198600101-00016
发表时间：
1984
期刊：
Arzneimittel-Forschung
影响因子：
--
作者：
B. Schölkens;R. Becker;J. Kaiser
通讯作者：
J. Kaiser