Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease.
Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease.
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DOI：
10.3389/fimmu.2022.1103375
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
在这一概念分析中，我们提出了关于自身免疫性大疱性疾病(AIBD)的两个问题的概念，即(I)当前AIBD的命名需要结合分子数据进行更新和(Ii)寻常型天疱疮(PV)靠近自然体孔的“样”区域。Zillikens最近注意到了当前使用的命名法不充分的问题，他提议成立一个小组来更新它。德莫乔夫斯基更新这一术语的早期努力碰巧是一项艰巨的任务。然而，理想的命名法应该保留几代皮肤科医生习惯的大量临床数据，包括已知的触发因素，并包括揭示自身免疫反应靶点和涉及的免疫球蛋白亚型的分子数据。受PV影响的自然体口之前在许多出版物中都有描述。然而，在这些出版物中，这些开口是单独描述的。在这里，Dmochowski提出了一个智力上的概念，即PV的这种倾向将这种疾病看似不同的临床特征统一了起来。
In this conceptual analysis, we present our concepts on two issues regarding autoimmune bullous diseases (AIBD), namely (i) current nomenclature of AIBD requires updating by incorporating molecular data and (ii) pemphigus vulgaris (PV) “likes” areas adjacent to natural body orifices. The problem of inadequacy of the currently used nomenclature was noticed recently by Zillikens, who proposed to form a group with the task of updating it. The early efforts by Dmochowski to update this nomenclature happened to be a daunting task. Nevertheless, the ideal nomenclature should retain the bulk of clinical data, which generations of dermatologists are accustomed to, including triggers if known, and incorporate molecular data revealing targets of autoimmune response and immunoglobulin isotypes involved. The natural body orifices affected by PV were previously described in numerous publications. However, these openings are described separately in these publications. Here, Dmochowski comes up with an intellectual concept that this propensity of PV unifies seemingly diverse clinical features of this disease.
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影响因子：
1.4
作者：
Jalowska, Magdalena;Gornowicz-Porowska, Justyna;Seraszek-Jaros, Agnieszka;Bowszyc-Dmochowska, Monika;Kaczmarek, Elzbieta;Dmochowski, Marian
通讯作者：
Dmochowski, Marian
影响因子：
3.9
作者：
Pietkiewicz, Pawel;Bowszyc-Dmochowska, Monika;Dmochowski, Marian
通讯作者：
Dmochowski, Marian
影响因子：
13.8
作者：
Boch, Katharina;Hammers, Christoph M.;Schmidt, Enno
通讯作者：
Schmidt, Enno
影响因子：
1.4
作者：
Gornowicz-Porowska, Justyna;Seraszek-Jaros, Agnieszka;Bowszyc-Dmochowska, Monika
通讯作者：
Bowszyc-Dmochowska, Monika
影响因子：
3.9
作者：
通讯作者：
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