Fibrinogen, red blood cells, and factor XIII in venous thrombosis.

Fibrinogen, red blood cells, and factor XIII in venous thrombosis.
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DOI:
10.1111/jth.12918
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发表时间:
2015-06
期刊:
Journal of thrombosis and haemostasis : JTH
影响因子:
--
通讯作者:
Wolberg AS
Wolberg AS
中科院分区:
其他
文献类型:
--
作者:
Walton BL;Byrnes JR;Wolberg AS

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心血管疾病是全世界死亡和残疾的主要原因。在心血管死亡原因中,静脉血栓形成(VT)在世界上排名第三。静脉血栓具有较高的红细胞和纤维蛋白含量;然而,对静脉血栓组成和稳定性的病理生理机制仍知之甚少。本文综述了纤维蛋白原、因子XIII和红细胞对VT的生物学、生物化学和生物物理学贡献,以及提示这些成分之间相互作用介导静脉血栓成分和大小的新证据。
Cardiovascular disease is the leading cause of death and disability worldwide. Among cardiovascular causes of death, venous thrombosis (VT) is ranked third most common in the world. Venous thrombi have high red blood cell and fibrin content; however, the pathophysiologic mechanisms that contribute to venous thrombus composition and stability are still poorly understood. This article reviews biological, biochemical, and biophysical contributions of fibrinogen, factor XIII, and red blood cells to VT, and new evidence suggesting interactions between these components mediate venous thrombus composition and size.
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