Intestinal infection with Mycobacterium avium in acquired immune deficiency syndrome (AIDS). Histological and clinical comparison with Whipple's disease.
Intestinal infection with Mycobacterium avium in acquired immune deficiency syndrome (AIDS). Histological and clinical comparison with Whipple's disease.
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获得性免疫缺陷综合征（艾滋病）中鸟分枝杆菌的肠道感染。
DOI：
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发表时间：
1985
影响因子：
3.1
通讯作者：
P. Volberding
中科院分区：
文献类型：
--
作者：
Robert I. Roth;Robert I. Roth;Robert L. Owen;Robert L. Owen;David F. Keren;David F. Keren;P. Volberding;P. Volberding
在内窥镜检查中，一名患有获得性免疫缺陷综合征（AIDS）、卡波西肉瘤、腹泻和不明原因吸收不良的30岁男性患者，通过组织学和电子显微镜检查显示与维普莱病一致的黄斑十二指肠病变。四环素对症状无反应。随后的培养显示系统性鸟分枝杆菌（M.禽）感染。本例患者、维普莱病患者和M.鸟类进行了比较。除M.抗酸染色阳性和细菌分型抗血清间接免疫荧光染色模式的差异可区分禽流感。肠固有层中PAS阳性巨噬细胞不再是维普莱病的特征性表现。维普莱病和M.禽流感感染表明，这两种都是免疫缺陷的表现，限制了巨噬细胞吞噬后对特定细菌的破坏。M.在艾滋病和其他免疫抑制疾病患者腹泻的鉴别诊断中，必须考虑禽流感。
At endoscopy, a 30-year-old man with acquired immune deficiency syndrome (AIDS), Kaposi's sarcoma, diarrhea, and unexplained malabsorption showed erythematous macular duodenal lesions consistent with Whipple's disease by histology and electron microscopy. Symptoms did not respond to tetracycline. Subsequent cultures revealed systemic Mycobacterium avium (M. avium) infection. Tissue from this patient, from patients with Whipple's disease and from a macaque with M. avium were compared. All contained PAS-positive macrophages but M. avium could be distinguished by positive acid-fast stains and a difference in pattern of indirect immunofluorescence staining with bacterial typing antisera. PAS-positive macrophages in the intestinal lamina propria are no longer pathognomonic of Whipple's disease. Ultrastructural and histological similarities between Whipple's disease and M. avium infection suggest that both are manifestations of immune deficits limiting macrophage destruction of particular bacteria after phagocytosis. M. avium must be considered in the differential diagnosis of diarrhea in patients with AIDS and other immunosuppressed conditions.
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获得性免疫缺陷综合征中的播散性鸟胞内分枝杆菌感染，类似于惠普尔氏病。
影响因子：
29.4
作者：
Gillin,JS;Urmacher,C;West,R;Shike,M
通讯作者：
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患有获得性细胞介导免疫缺陷的同性恋男性中传播的鸟胞内分枝杆菌感染：两例病例的组织学和免疫学研究。
影响因子：
3.5
作者：
Sohn,CC;Schroff,RW;Kliewer,KE;Lebel,DM;Fligiel,S
通讯作者：
Fligiel,S
影响因子：
6.4
作者：
DESTEFANO, E;FRIEDMAN, RM;VILCEK, J
通讯作者：
VILCEK, J
一名先前健康的典型血友病患者出现获得性免疫缺陷综合征，伴有卡氏肺孢子虫肺炎和鸟分枝杆菌细胞内感染。
影响因子：
39.2
作者：
Poon,MC;Landay,A;Prasthofer,EF;Stagno,S
通讯作者：
Stagno,S