Isoflurane inhalation anesthesia should be a new requirement in intracavernosal pressure detection-the gold standard of erectile function assessment.
Isoflurane inhalation anesthesia should be a new requirement in intracavernosal pressure detection-the gold standard of erectile function assessment.
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异氟烷吸入麻醉应成为海绵体内压检测的新要求——勃起功能评估的金标准
DOI：
10.1038/s41598-017-15020-5
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发表时间：
2017-11-02
影响因子：
4.6
通讯作者：
Yuan J
中科院分区：
文献类型：
--
作者：
Li J;Wu C;Fu F;You X;Gao L;Wazir R;Qin F;Han P;Yuan J
海绵体内压（ICP）是动物勃起功能检测的金标准，但对于应采用何种麻醉方案尚未达成共识。16只成年雄性Sprague-Dawley大鼠随机分为两组。A组腹腔注射水合氯醛。B组大鼠在5%异氟醚中诱导3 min，然后在1.0 ~ 1.5%异氟醚中维持。实验期间监测平均动脉压（MAP）、呼吸频率（RR）和心率。ICP检测后采集尾静脉、颈动脉血。B组最大ICP值、MAP、ICP/MAP比值均显著高于A组，RR低于B组，心率高于B组。各组间pO2、pCO2均无显著差异。而数据显示，A组动物相对低氧。异氟醚吸入麻醉对勃起功能的检测比水合氯醛腹腔麻醉作用下的检测能提供相对稳定的生理状态。异氟醚吸入性麻醉更适合于ICP试验。
Intracavernosal pressure (ICP) is gold standard for the detection of erectile function in animals, but no consensus has yet been achieved on what kind of anesthetic protocol should be applied. A total of 16 adult male Sprague-Dawley rats were randomized into two groups. In group A, chloral hydrate was injected intraperitoneally. Rats in group B were induced in 5% isoflurane for 3 min and then maintained in 1.0–1.5% isoflurane. Mean arterial pressure (MAP), respiratory rate (RR) and heart rate were monitored during all experiments. After ICP detection, tail vein and carotid artery blood were collected. The maximum ICP value, MAP and ICP/MAP ratio in group B was significantly higher than in that of group A. The RR in group A was lower than in that of group B, but the heart rate in group A was higher than in group B. There were no significant differences in both pO2 and pCO2 between groups. While the data showed that animals in group A were relatively hypoxemic. Isoflurane inhalation anesthesia in detection of erectile function could offer a relatively more stable physical state than in that under the effect of chloral hydrate intraperitoneal anesthesia. Isoflurane inhalation anesthesia is more suitable for ICP test.
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