High-frequency neuromodulation improves obsessive-compulsive behavior.
High-frequency neuromodulation improves obsessive-compulsive behavior.
复制标题
高频神经调节改善强迫行为。
DOI：
10.1038/s41591-020-01173-w
复制
发表时间：
2021-03
期刊：
影响因子：
82.9
通讯作者：
Reinhart, Robert M. G.
中科院分区：
文献类型：
--
作者：
Grover, Shrey;Nguyen, John A.;Viswanathan, Vighnesh;Reinhart, Robert M. G.
全世界有近10亿人患有强迫行为，但我们对这些行为的机械理解是不完整的，并且没有有效的治疗方法。一种新兴的观点将强迫行为描述为适应不良的习惯学习，这可能与奖励处理过程中眶额-纹状体回路的异常β-γ神经生理学有关。我们用交流电靶向眶额皮层，根据奖励网络的内在β-γ频率进行个性化设置，并显示出对奖励引导的选择行为和学习的快速、可逆、频率特异性调制，而不是惩罚引导的选择行为和学习，这是由行动者-批评者架构中增加的探索驱动的。接下来，我们证明，长期应用该程序超过5天，可在3个月内有力地减弱非临床人群的强迫行为，其中症状更严重的个体获益最大。最后，我们表明，收敛机制调制奖励学习和减少强迫症状的基础。这些结果有助于奖励，学习和强迫行为的神经生理学理论，表明β-γ范围内节奏的统一功能作用，并为相关疾病的个性化电路治疗的发展奠定了基础。
Nearly one billion people worldwide suffer from obsessive-compulsive behaviors, yet our mechanistic understanding of these behaviors is incomplete, and effective therapeutics are unavailable. An emerging perspective characterizes obsessive-compulsive behaviors as maladaptive habit learning, which may be associated with abnormal beta-gamma neurophysiology of the orbitofrontal-striatal circuitry during reward processing. We target the orbitofrontal cortex with alternating current, personalized to the intrinsic beta-gamma frequency of the reward network, and show rapid, reversible, frequency-specific modulation of reward- but not punishment-guided choice behavior and learning, driven by increased exploration in the setting of an actor-critic architecture. Next, we demonstrate that chronic application of the procedure over 5 days robustly attenuates obsessive-compulsive behavior in a non-clinical population for 3 months, with the largest benefits for individuals with more severe symptoms. Finally, we show that convergent mechanisms underlie modulation of reward learning and reduction of obsessive-compulsive symptoms. The results contribute to neurophysiological theories of reward, learning and obsessive-compulsive behavior, suggest a unifying functional role of rhythms in the beta-gamma range, and set the groundwork for the development of personalized circuit-based therapeutics for related disorders.
登录
查看更多内容
影响因子：
3.6
作者：
Foa, EB;Huppert, JD;Salkovskis, PM
通讯作者：
Salkovskis, PM
影响因子：
5.7
作者：
Edwards, Dylan;Cortes, Mar;Datta, Abhishek;Minhas, Preet;Wassermann, Eric M.;Bikson, Marom
通讯作者：
Bikson, Marom
DOI：
10.1098/rstb.2007.2098
发表时间：
2007-05-29
影响因子：
6.3
作者：
Cohen, Jonathan D.;McClure, Samuel M.;Yu, Angela J.
通讯作者：
Yu, Angela J.
影响因子：
4.1
作者：
Hajcak, G;Huppert, JD;Foa, EB
通讯作者：
Foa, EB
影响因子：
17.7
作者：
Fullana, Miguel A.;Mataix-Cols, David;Poulton, Richie
通讯作者：
Poulton, Richie