Small-size circulating endothelial microparticles in coronary artery disease.
Small-size circulating endothelial microparticles in coronary artery disease.
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冠状动脉疾病中的小尺寸循环内皮微粒
DOI：
10.1371/journal.pone.0104528
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Xiu RJ
中科院分区：
文献类型：
--
作者：
Hu SS;Zhang HG;Zhang QJ;Xiu RJ
最近的一些证据表明，内皮微粒是一种新的生物标志物，可用于监测冠状动脉疾病（CAD）的内皮功能障碍。然而，关于小颗粒（直径<0.5µm）的检测数据缺乏。本研究的目的是检测CAD患者的小尺寸内皮微粒（SEMPs）以监测内皮功能障碍。方法共招募19例冠心病患者和14例健康人。流式细胞术检测CD31+/CD42b−SEMPs和CD62E+ SEMPs的绝对数量和百分比。同时记录临床参数。结果冠心病患者组CD62E+ SEMPs的平均百分比高于健康人组。CD62E+ SEMPs百分比的受试者工作特征曲线下面积为0.795，截断值为1.35。CD62E+ SEMPs百分比与各项临床参数无相关性。结论CD62E+ SEMPs百分比是监测冠心病内皮功能的潜在生物标志物。
Objectives Several recent lines of evidence indicate that endothelial microparticles are a new biomarker that can be used to monitor endothelial dysfunction in coronary artery disease (CAD). However, data concerning the detection of small microparticles (diameter <0.5 µm) are lacking. The aim of this study was to detect small-size endothelial microparticles (SEMPs) in CAD patients to monitor endothelial dysfunction. Methods In total, 19 CAD patients and 14 healthy subjects were recruited. The absolute numbers and percentages of CD31+/CD42b− SEMPs and CD62E+ SEMPs were determined by flow cytometry. Clinical parameters were also recorded. Results The mean percentage of CD62E+ SEMPs was higher in the CAD patient group than in the healthy subject group. The area under the receiver operating characteristic curve of the percentage of CD62E+ SEMPs was 0.795, and the cut-off value was 1.35. There was no correlation between the percentage of CD62E+ SEMPs and various clinical parameters. Conclusion The percentage of CD62E+ SEMPs is a potential biomarker for monitoring endothelial function in CAD.
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影响因子：
8.3
作者：
Preston, RA;Jy, W;Alm, YS
通讯作者：
Alm, YS
DOI：
10.1161/atvbaha.111.244616
发表时间：
2012-04-01
影响因子：
8.7
作者：
Robert, Stephane;Lacroix, Romaric;Dignat-George, Francoise
通讯作者：
Dignat-George, Francoise
影响因子：
10.4
作者：
Yuana, Y.;Oosterkamp, T. H.;Osanto, S.
通讯作者：
Osanto, S.
影响因子：
18.2
作者：
Nozaki, Toshimitsu;Sugiyama, Seigo;Ogawa, Hisao
通讯作者：
Ogawa, Hisao
DOI：
10.1161/01.atv.0000191634.13057.15
发表时间：
2006-01-01
影响因子：
8.7
作者：
Werner, N;Wassmann, S;Nickenig, G
通讯作者：
Nickenig, G