ESM-CT: a precise method for localization of DBS electrodes in CT images.
ESM-CT: a precise method for localization of DBS electrodes in CT images.
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DOI：
10.1016/j.jneumeth.2018.09.009
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发表时间：
2018-10-01
影响因子：
3
通讯作者：
Norris SA
中科院分区：
文献类型：
--
作者：
Milchenko M;Snyder AZ;Campbell MC;Dowling JL;Rich KM;Brier LM;Perlmutter JS;Norris SA
丘脑底核的脑深部电刺激（DBS）对帕金森病产生不同的影响。相对于目标的不同电极位置可能导致变化。因此，在研究DBS效应时，精确的电极定位至关重要。我们开发了一种半自动方法，即CT图像中的电极轴建模（ESM-CT），以重建DBS电极导线轨迹和接触位置。我们评估了方法学对操作者依赖性步骤的敏感性、对图像重现的稳健性和重测重复性。在56例患者中应用ESM-CT，以研究植入后即刻（DBS-CT）和数月后（DEL-CT）采集的图像之间的电极位置变化（以及与扫描之间的时间、术后硬膜下空气量和采集期间头部倾斜的关系）。电极头端定位对图像重现具有鲁棒性，并且在测试-重新测试比较中可复制到约0.2 mm范围内。DBS-CT和DEL-CT扫描之间出现了系统性的头-腹-外侧电极移位。头部角度是主要的解释因素（p<0.001，Pearson's r=0.46，两侧），硬膜下空气量对电极位移的预测作用较弱（p= 0.02，r =0.29：p= 0.1，r =0.25，左右侧）。DEL-CT中的模型轴曲率略大。位移的大小和弯曲程度与扫描之间的时间无关。ESM-CT与两种现有方法的比较显示，一种方法在一个坐标（1± 0.3mm，p <0.001）和另一种方法在三个坐标（x：0.1±0.1mm，y：0.4 ± 0.2mm，z：0.4± 0.2mm，p<10−10）上存在系统差异。受试者的方法内坐标变异性相似。我们描述了一个强大的和精确的方法CT DBS接触定位。应用表明，采集头角度显著影响电极位置。DBS定位方案应考虑头部角度。
Deep brain stimulation (DBS) of the subthalamic nucleus produces variable effects in Parkinson disease. Variation may result from different electrode positions relative to target. Thus, precise electrode localization is crucial when investigating DBS effects. We developed a semi-automated method, Electrode Shaft Modeling in CT images (ESM- CT) to reconstruct DBS lead trajectories and contact locations. We evaluated methodological sensitivity to operator-dependent steps, robustness to image resampling, and test-retest replicability. ESM-CT was applied in 56 patients to study electrode position change (and relation to time between scans, postoperative subdural air volume, and head tilt during acquisition) between images acquired immediately post-implantation (DBS-CT) and months later (DEL-CT). Electrode tip localization was robust to image resampling and replicable to within ~0.2mm on test-retest comparisons. Systematic electrode displacement occurred rostral-ventral-lateral between DBS-CT and DEL-CT scans. Head angle was a major explanatory factor (p<0.001,Pearson’s r=0.46, both sides) and volume of subdural air weakly predicted electrode displacement (p=0.02,r=0.29:p=0.1,r=0.25 for left:right). Modeled shaft curvature was slightly greater in DEL-CT. Magnitude of displacement and degree of curvature were independent of elapsed time between scans. Comparison of ESM-CT against two existing methods revealed systematic differences in one coordinate (1±0.3mm,p <0.001) for one method and in three coordinates for another method (x:0.1±0.1mm, y:0.4±0.2mm, z:0.4±0.2mm, p<10−10). Within-method coordinate variability across participants is similar. We describe a robust and precise method for CT DBS contact localization. Application revealed that acquisition head angle significantly impacts electrode position. DBS localization schemes should account for head angle.
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影响因子：
7.7
作者：
Choi KS;Noecker AM;Riva-Posse P;Rajendra JK;Gross RE;Mayberg HS;McIntyre CC
通讯作者：
McIntyre CC
影响因子：
2.6
作者：
Campbell MC;Karimi M;Weaver PM;Wu J;Perantie DC;Golchin NA;Tabbal SD;Perlmutter JS;Hershey T
通讯作者：
Hershey T
影响因子：
7.7
作者：
Howell B;McIntyre CC
通讯作者：
McIntyre CC
影响因子：
14.5
作者：
Hershey, Tamara;Campbell, Meghan C.;Perlmutter, Joel S.
通讯作者：
Perlmutter, Joel S.
DOI：
10.1176/appi.neuropsych.11030060
发表时间：
2012-12-01
影响因子：
2.9
作者：
Campbell, Meghan C.;Black, Kevin J.;Hershey, Tamara
通讯作者：
Hershey, Tamara